Rivaroxaban: Uses, Interactions, Mechanism of Action - DrugBank …
Mechanism of action Rivaroxaban competitively inhibits free and clot bound factor Xa. Factor Xa is needed to activate prothrombin (factor II) to thrombin (factor IIa).
Rivaroxaban - StatPearls - NCBI Bookshelf
2023年4月17日 · Describe the mechanism of action of rivaroxaban. Outline the contraindications in a patient on rivaroxaban therapy. Review the importance of interprofessional team coordination and communication in treating and managing rivaroxaban therapy for …
Rivaroxaban - Wikipedia
Rivaroxaban, sold under the brand name Xarelto among others, is an anticoagulant medication (blood thinner) used to treat and prevent blood clots. [8] Specifically it is used to treat deep vein thrombosis and pulmonary emboli and prevent blood clots in atrial fibrillation and following hip or knee surgery. [ 8 ]
XARELTO - Mechanism of Action - Janssen Science
In vivo thrombosis and bleeding models in rats and rabbits showed that rivaroxaban produced a dose-dependent reduction in thrombus formation, inhibition of factor Xa activity, and PT prolongation without significant prolongation of bleeding times at the effective doses.
The mechanism of action of rivaroxaban--an oral, direct Factor Xa ...
Rivaroxaban competitively inhibits Factor Xa and is more than 10,000-fold more selective for Factor Xa than other related serine proteases, and it does not require cofactors (such as antithrombin) to exert its anticoagulant effect.
Clinical Pharmacokinetic and Pharmacodynamic Profile of …
Among these, rivaroxaban (Xarelto ®)—a direct Factor Xa inhibitor—was approved for clinical use in 2008 for the prevention of venous thromboembolism (VTE) in adults undergoing elective hip or knee replacement surgery.
Rivaroxaban: Dosage, Mechanism/Onset of Action, Half-Life
2020年2月17日 · Includes Rivaroxaban indications, dosage/administration, pharmacology, mechanism/onset/duration of action, half-life, dosage forms, interactions, warnings, adverse reactions, off-label uses and more.
Xarelto: Package Insert / Prescribing Information - Drugs.com
2024年11月4日 · XARELTO is indicated for the prophylaxis of venous thromboembolism (VTE) and VTE related death during hospitalization and post hospital discharge in adult patients admitted for an acute medical illness who are at risk for thromboembolic complications due to moderate or severe restricted mobility and other risk factors for VTE and not at high ...
The mechanism of action of rivaroxaban - Thrombosis Research
2010年5月7日 · Rivaroxaban – the first oral, direct Factor Xa inhibitor – is a small-molecule oxazolidinone derivative that binds directly and reversibly to Factor Xa via the S1 and S4 pockets.
Pharmacokinetic Properties of Rivaroxaban in Healthy Human …
In this review, the mechanism of action and the pharmacokinetic properties of rivaroxaban in healthy subjects were outlined. Rivaroxaban is a direct, reversible and highly selective factor Xa inhibitor that inhibits thrombin generation at therapeutically relevant concentrations.