T cell receptor (TCR) signaling in health and disease | Signal ...
2021年12月13日 · This review provides a comprehensive snapshot of the various molecules involved in regulating T cell receptor signaling, covering both enzymes and adaptors, and will discuss their role in human...
Recent insights of T cell receptor-mediated signaling pathways for T ...
2020年5月21日 · Naive T cells are initially activated through their TCRs by antigen/MHC complexes expressed by antigen-presenting cells. Subsequent signals, including environmental cues and signaling through...
T-Cell Activation: Two for T: Current Biology - Cell Press
It is now well established that two signals are required to activate T cells — one is the antigen-specific signal transmitted by the T-cell receptor, the other a ‘costimulatory’ signal that is provided by interactions between pairs of molecules, one expressed on the surface of the T cell and the other on the surface of the antigen ...
Two signal models in innate immunity - PubMed
In the classic two-signal model of T-cell activation, signal one consists of engagement of the T-cell receptor by antigen/major histocompatibility complex, whereas signal two arises from costimulatory ligands on antigen-presenting cells. A requirement for two independent signals helps to ensure that T-cell responses are initiated only in ...
T-cell activation | British Society for Immunology
Once the T cell has received a specific antigen signal and a general signal two, it receives more instructions in the form of cytokines. These determine which type of responder the cell will become – in the case of helper T cells, it will push them into Th1 type (cells exposed to the cytokine IL-12), Th2 (IL-4), or IL-17 (IL-6, IL-23).
The two-signal model of T-cell activation after 30 years
2002年1月15日 · The two-signal model of T-cell activation is still valid after 30 years. The recent understanding of the first signal intricacy and its tight relationship with the second signal have thrown decisive light on T-cell activation processes and the complex molecular events that occur on the surface and w …
A photo-activable nano-agonist for the two-signal model of T cell …
2023年9月1日 · Schematic illustration of T cell-mediated antitumor immune responses enhanced by photo-activable nano-agonist for the two-signal model, which improved the in vivo activation and expansion of cytotoxic T lymphocytes (CTLs) with precision and safety.
Integrative biology of T cell activation | Nature Immunology
2014年8月19日 · Using as an example the scaffolding molecule Lat ('linker for the activation of T cells'), a key signaling hub of the TCR signal-transduction network, we illustrate in this Perspective the...
T cell activation requires 2 signals: TCR and costimulation. Lack of costimulation during T cell activation leads to anergy. T cell responses are downregulated by CTLA-4 and Fas
T-cell activation. Two for T - PubMed
1995年8月1日 · T-cell activation requires costimulation in addition to the antigen-specific signal. Recent results suggest that distinct costimulatory molecules can specifically activate different types of T-cell response.
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