Receptor-mediated endocytosis - Wikipedia
Receptor-mediated endocytosis (RME), also called clathrin-mediated endocytosis, is a process by which cells absorb metabolites, hormones, proteins – and in some cases viruses – by the inward budding of the plasma membrane (invagination).
Key principles and methods for studying the endocytosis of
2021年3月12日 · CME is sometimes referred to as receptor-mediated endocytosis; however, this term is outdated and misleading, as clathrin-independent internalization mechanisms can also involve specific...
An overview of receptor endocytosis and signaling - ScienceDirect
2023年1月1日 · Receptor endocytosis can occur through clathrin-dependent and clathrin-independent pathways. This chapter briefly discusses the internalization, trafficking, and signaling of various receptors in normal conditions. In addition, it also highlights the malfunction of the receptor in disease conditions. Previouschapter in volume. Nextchapter in volume
Designed endocytosis-inducing proteins degrade targets and
2024年9月25日 · We present EndoTags for insulin-like growth factor 2 receptor (IGF2R) and asialoglycoprotein receptor (ASGPR), sortilin and transferrin receptors, and show that fusing these tags to soluble or...
An overview of receptor endocytosis and signaling - PubMed
Receptor endocytosis can occur through clathrin-dependent and clathrin-independent pathways. This chapter briefly discusses the internalization, trafficking, and signaling of various receptors in normal conditions. In addition, it also highlights the malfunction of …
Impact of Endocytosis Mechanisms for the Receptors Targeted by …
Endocytosis of a biopharmaceutical upon binding to a cell surface receptor is the underlying cause of target-mediated drug clearance. ADC internalization kinetics most likely have a significant impact on efficacy and off-tumor side effects.
To degrade or not to degrade: mechanisms and significance of …
2018年9月7日 · The sorting of integral cell surface proteins, including signalling receptors, nutrient transporters, ion channels, adhesion molecules and polarity markers, within the endolysosomal network for...
Impact of Endocytosis Mechanisms for the Receptors Targeted by …
2021年7月15日 · Biologically-based therapies increasingly rely on the endocytic cycle of internalization and exocytosis of target receptors for cancer therapies. However, receptor trafficking pathways (endosomal sorting (recycling, lysosome localization) and lateral membrane movement) are often dysfunctional in can ….
Endocytosis - The Cell - NCBI Bookshelf
Receptor-Mediated Endocytosis. In contrast to phagocytosis, which plays only specialized roles, pinocytosis is common among eukaryotic cells. The best-characterized form of this process is receptor-mediated endocytosis, which provides a mechanism for the selective uptake of specific macromolecules (Figure 12.36). The macromolecules to be ...
Transport into the Cell from the Plasma Membrane: Endocytosis
Receptor-mediated endocytosis provides a selective concentrating mechanism that increases the efficiency of internalization of particular ligands more than a hundredfold, so that even minor components of the extracellular fluid can be specifically taken up in large amounts without taking in a correspondingly large volume of extracellular fluid.