palmitoleoyl-CoA | C37H64N7O17P3S | CID 25244394 - PubChem
Palmitoleoyl-CoA is a long-chain fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of palmitoleic acid. It is an 11,12-saturated fatty acyl-CoA and a hexadecenoyl-CoA. It is functionally related to a palmitoleic acid. It is a conjugate acid of a palmitoleoyl-CoA(4-).
科学网—《自然》：李晓淳研究组揭示PORCN识别底物的分子基础 …
2022年7月15日 · 在解析反应产物的结构时，作者使用了人工合成的产物类似物捕捉到了反应结束后乙酰化产物的瞬时状态。该复合物结构显示出棕榈油酰化Wnt3A-Hairpin2的脂肪酰基也具有和Palmitoleoyl-CoA的脂肪酰基类似的蜷缩状态，进一步证明了PORCN对于Palmitoleoyl-CoA的高度 …
Palmitoleoylation - Wikipedia
In palmitoleoylation, a palmitoleoyl group (derived from palmitoleic acid, pictured above) is added.. Palmitoleoylation is type of protein lipidation where the monounsaturated fatty acid palmitoleic acid is covalently attached to serine or threonine residues of proteins. [1] [2] Palmitoleoylation appears to play a significant role in trafficking and targeting and function of Wnt proteins.
Modulators for palmitoylation of proteins and small molecules
2024年5月5日 · As an essential form of lipid modification for maintaining vital cellular functions, palmitoylation plays an important role in in the regulation of various physiological processes, serving as a promising therapeutic target for diseases like cancer and neurological disorders.
Nature | 李晓淳团队揭示PORCN催化Wnt酰化的反应机理医药新闻 …
2022年7月14日 · 人体中有19种不同Wnt蛋白且均可由PORCN催化修饰，与此相反，PORCN只使用棕榈油酰辅酶A （Palmitoleoyl-CoA）作为底物。 因PORCN对Wnt信号通路的高度专一性，PORCN成为了Wnt相关癌症的重要靶点之一，有多种抑制剂应用于治疗癌症的临床试验中。
Mechanisms and Inhibition of Porcupine-Mediated Wnt Acylation
Wnt proteins must undergo palmitoleoylation on their hairpin 2 by the endoplasmic reticulum (ER)-resident membrane-bound O-acyltransferase porcupine (PORCN) before acting as signaling molecules 5 – 7. This modification is indispensable for Wnt to bind its receptor Frizzled, thus triggering signaling 8.
Chemical Probes to Directly Profile Palmitoleoylation of Proteins
2016年11月11日 · Palmitoleoylation is a unique lipid modification of proteins, where a monounsaturated fatty acid, palmitoleic acid (C16:1), is covalently attached to proteins. Wnt proteins are known to be palmitoleoylated by cis -Δ9 palmitoleate at conserved serine residues.
Mechanisms and inhibition of Porcupine-mediated Wnt acylation
2022年7月13日 · Here we report four cryo-electron microscopy structures of human PORCN: the complex with the palmitoleoyl-coenzyme A (palmitoleoyl-CoA) substrate; the complex with the PORCN inhibitor LGK974,...
Palmitoleoyl coenzyme A 90 18198-76-0 - MilliporeSigma
Coenzyme A functions as an acyl group carrier, acetyl-CoA. Palmitoleoyl coenzyme A (Palmitoleoyl-CoA) may be used in comparative long chain fatty acyl-CoA studies such as the effects of long-chain acyl-coenzyme A esters on cardiac …
palmitoleoyl-CoA(4-) | C37H60N7O17P3S-4 | CID 25244393
Palmitoleoyl-CoA(4-) is a hexadecenoyl-CoA(4-) obtained by deprotonation of the phosphate and diphosphate OH groups of palmitoleyl-CoA. It has a role as a human metabolite and a Saccharomyces cerevisiae metabolite. It is a conjugate base of a palmitoleoyl-CoA.
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