Nature重磅：Senolytics之父带你一文读懂衰老细胞清除机制与治疗 …
清除衰老细胞的疗法——Senolytic疗法. 既然是衰老细胞引起了衰老，那么从理论上来讲清除衰老细胞就可以延缓衰老，科学家们根据这个思路开发出了Senolytic疗法，“seno”是衰老的意 …
Cellular senescence and senolytics: the path to the clinic
2022年8月11日 · These genetic models have been useful in pinpointing those cells expressing particular senescence-linked markers (for example, p16 INK4a or p21 CIP1/WAF1) and as …
Senolytic therapy alleviates physiological human brain aging
2023年11月13日 · In the brains of SARS-CoV-2-infected K18-hACE2 mice we found that senolytic treatment alleviates p16 and the levels of proinflammatory cytokines that may be due, in part, …
Chronic social stress induces p16-mediated senescent cell
4 天之前 · p16 Ink4a-positive SNCs can drive aging-related diseases and shorten ... P. et al. Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and …
First evidence that senolytics are effective at decreasing senescent ...
2019年9月19日 · The findings suggest that senolytics given intermittently in a ‘hit-and-run’ fashion, despite the elimination half-lives of D and Q being <11 h, is effective at reducing …
A pipeline for senolytics - PMC - National Center for …
2024年5月5日 · Lee et al. developed an approach for high-throughput screening of senolytic compounds. In Lee et al. , senescence is induced in mice that express a highly sensitive p16 …
Senolytic targets and new strategies for clearing senescent cells
2021年4月1日 · Multiple stressors and damaging stimuli activate pathways that converge on the activation of cell cycle inhibitors. Senescent cells are characterized by enlarged and irregular …
Identifying specific functional roles for senescence across cell types
2024年10月4日 · This study illuminates the functional diversity of p16 Ink4a+ cells and offers insights for developing cell-type-specific senolytic therapies in the future.
A senolytic immunotoxin eliminates p16 - PubMed
We herein describe a novel approach to eliminate p16-expressing cells from mice at any given point in time, generating a new type of knock-in model, p16hCD2 mice and a toxin-conjugated …
Multiparametric senescent cell phenotyping reveals targets of senolytic …
2023年7月31日 · These p16 + Ki67-BCL-2+ cells are highly enriched for senescence-associated secretory phenotype and DNA damage markers, are strongly associated with age, and their …