Bacterial outer membrane vesicles as cationic dye carriers for ...
2023年4月17日 · We demonstrate that cationic dyes (IR780, Cy7, and Cy7.5) form stable complexes with negatively charged bacterial-OMVs, improving the dyes’ in vivo circulation and optoacoustic properties. Such OMV-Dye complexes are biodegradable and …
Bacterial outer membrane vesicles suppress tumor by interferon …
2017年9月20日 · Cy7-labeled OMVs (10 μg in total protein) were injected intravenously to normal mice and mice bearing tumor with a diameter of 15 mm (male, 8 weeks old).
Enhancing immune responses of ESC-based TAA cancer vaccines …
2024年1月3日 · Bacterial outer membrane vesicles (OMVs) can serve as immunoadjuvants and act as a delivery vector for tumor antigens. In the current study, we engineered a new OMV platform for the co-delivery of ESC-derived tumor antigens …
Bioengineered bacteria-derived outer membrane vesicles as a …
2021年4月6日 · We used this OMV-based platform to deliver a series of tumor antigens in murine tumor models and demonstrated excellent antigen-specific T-lymphocyte-mediated anti-tumor immune responses.
Engineered bacterial outer membrane vesicles: a versatile bacteria ...
Outer membrane vesicles (OMVs) are nanoscale lipid bilayer structures released by gram-negative bacteria. They share membrane composition and properties with their originating cells, making them adept at traversing cellular barriers.
We demonstrate that cationic dyes (IR780, Cy7, and Cy7.5) form stable com-plexes with negatively charged bacterial-OMVs, improving the dyes’ in vivo circulation and optoacoustic properties. Such OMV-Dye complexes are biodegradable and safe for in vivo applications.
Bacterial Outer Membrane Vesicles Loaded with Perhexiline …
2023年7月7日 · M2-like macrophages, occupying a major role in TAMs, can be repolarized into anti-tumoral phenotypes. In this study, outer membrane vesicles (OMVs) secreted by Escherichia coli Nissle 1917 carry perhexiline (OMV@Perhx) to explore the influence of OMVs and perhexiline on TAM repolarization.
Bacterial outer membrane vesicles as cationic dye carriers for ...
2023年4月17日 · It is demonstrated that cationic dyes (IR780, Cy7, and Cy7.5) form stable complexes with negatively charged bacterial-OMVs, improving the dyes’ in vivo circulation and optoacoustic properties, and the efficient tumor accumulation of OMV-Dyes enables sensitive tumor detection using optoACoustic technology.
Personalized cancer vaccines from bacteria-derived outer …
2022年1月1日 · Together, our data suggest that both OMV-OVA-IgG and OMV-OVA-DEC can stimulate a T cell-mediated immune response and marked CTL-mediated specific immune elimination of antigen-positive target cells, with the OMV-OVA-DEC vaccine most potent in this function, likely because of the targeting antibody decoration.
Bacterial outer membrane vesicles as cationic dye carriers for ...
2023年4月17日 · Results We demonstrate that cationic dyes (IR780, Cy7, and Cy7.5) form stable complexes with negatively charged bacterial-OMVs, improving the dyes’ in vivo circulation and optoacoustic...
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