Notoamides A-D: prenylated indole alkaloids isolated from a …
Affiliation 1 Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920-1192, Japan. sachiko@p.kanazawa-u.ac.jp
Prenylated notoamide-type alkaloids isolated from the fungus ...
2022年11月1日 · Notoamides are a family of prenylated indole alkaloids with unusual ring systems and possessing a range of significant pharmaceutical activities. Based on LC-MS/MS and genome orientations, ten undescribed notoamide-type alkaloids namely sclerotiamides I-R were isolated from a marine gorgonian-derived fungus Aspergillus sclerotiorum LZDX-33-4.
Synthesis of Notoamide J: A Potentially Pivotal Intermediate in the ...
An efficient total synthesis of notoamide J, a new prenylated indole alkaloid and potential biosynthetic precursor, is described herein. Starting from l-proline and a substituted tryptophan derivat...
Notoamide O, a Structurally Unprecedented Prenylated Indole …
2010年7月13日 · Notoamides O−R were isolated from a marine-derived Aspergillus sp. Notoamide O possesses a novel hemiacetal/hemiaminal ether functionality hitherto unknown among this family of prenylated indole alkaloids.
Notoamide E: biosynthetic incorporation into notoamides C …
2011年4月20日 · Notoamide E, a short-lived secondary metabolite, has been proposed as a biosynthetic intermediate to several advanced metabolites isolated from Aspergillus versicolor. In order to verify the role of this indole alkaloid along the biosynthetic pathway, synthetic doubly 13 C-labeled notoamide E was fed to Aspergillus versicolor .
Notoamide A | C26H29N3O5 | CID 16128040 - PubChem
Notoamide A | C26H29N3O5 | CID 16128040 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
STUDIES ON THE BIOSYNTHESIS OF THE STEPHACIDINS AND …
2010年12月12日 · The synthesis of notoamide S (8) was accomplished in seven steps from known indole 14 in 19% overall yield. Synthetic access to this potentially pivotal intermediate, will allow us to further interrogate the steps from notoamide S to the distinct natural enantiomers of stephacidin A and notoamide B.
Notoamide-type alkaloid induced apoptosis and autophagy
2019年6月25日 · Notoamide G activated the expression of caspase-3, caspase-8, and caspase-9, in association with the degradation of the downstream gene PARP in a dose-dependent manner, suggesting that notoamide G induced apoptosis via a mitochondrial pathway and a dead receptor-mediated pathway.
Notoamide-type alkaloid induced apoptosis and ... - RSC Publishing
2019年6月25日 · Notoamide G activated the expression of caspase-3, caspase-8, and caspase-9, in association with the degradation of the downstream gene PARP in a dose-dependent manner, suggesting that notoamide G induced apoptosis via a mitochondrial pathway and a dead receptor-mediated pathway.
Bioconversion of 6-epi-Notoamide T produces metabolites of ...
2015年1月1日 · The Notoamides are a family of prenylated indole alkaloids produced by the marine-derived A. sp. MF297-2, 1 and have also been detected as natural metabolites of A. versicolor NRRL 35660. 2 These natural substances contain a unique bicyclo [2.2.2]diazaoctane core structure and have attracted significant attention from the synthetic community. 3 ...
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