Mitochondrial unfolded protein response - Wikipedia
The mitochondrial unfolded protein response (UPRmt) is a cellular stress response related to the mitochondria. The UPR mt results from unfolded or misfolded proteins in mitochondria beyond …
The mitochondrial UPR: mechanisms, physiological functions and …
2017年11月22日 · The mitochondrial unfolded protein response (UPR mt) is a transcriptional response that is activated by multiple forms of mitochondrial dysfunction and regulated by …
A cytosolic surveillance mechanism activates the mitochondrial UPR
2023年6月7日 · We identify a highly controlled cytosolic surveillance mechanism that integrates independent mitochondrial stress signals to initiate the mitochondrial unfolded protein …
The mitochondrial UPR: mechanisms, physiological functions and …
The UPR mt promotes cell survival and the recovery of the mitochondrial network to ensure optimal cellular function. Recent insights into the regulation, mechanisms and functions of the …
Mitochondrial unfolded protein response: An emerging …
2021年2月1日 · Mitochondrial unfolded protein response (UPR mt) is a mitochondria stress response, which the transcriptional activation programs of mitochondrial chaperone proteins …
The mitochondrial UPR - protecting organelle protein homeostasis
2010年11月15日 · Here, we review the current knowledge of this mitochondrial unfolded protein response (UPR(mt)), compare it with the better understood UPR of the endoplasmic reticulum …
Mitochondrial unfolded protein response (UPRmt): what we …
This stress response is activated by the accumulation of unfolded/misfolded proteins within the mitochondrial matrix, which results in the transmission of a signal to the nucleus to increase …
UPR mt regulation and output: a stress response mediated by
2018年2月9日 · One such pathway is the mitochondrial unfolded protein response (UPR mt), which is regulated by the mitochondrial import efficiency of the transcription factor ATFS-1 in …
The mitochondrial unfolded protein response: Signaling from …
Cells use a variety of means to recover mitochondria and restore homeostasis, including the activation of retrograde pathways such as the mitochondrial unfolded protein response (UPR …
The mitochondrial unfolded protein response (UPR
2022年7月21日 · Mitochondrial unfolded protein response (UPR mt) is proposed to mediate mitochondrial maintenance in cancer. Cancer cells develop mitochondrial dysfunction due to …