Isotype (immunology) - Wikipedia
In immunology, antibodies (immunoglobulins (Ig)) are classified into several types called isotypes or classes. The variable (V) regions near the tip of the antibody can differ from molecule to molecule in countless ways, allowing it to specifically target an …
同种型（isotype）、同种异型（allotype）和独特型（idiotype）
2017年6月15日 · 根据抗体引起的是异种，同种，异体或者自体免疫应答，将抗体的免疫原性分为:同种型（isotype）、同种异型（allotype）和独特型（idiotype）。 同种型（isotype）: 同一物种内所有个体共同具有的Ig抗原特异性结构。同种型（isotype）抗体的抗原决定簇存在于CH和CL。
流式课堂 | 流式对照设置之同型对照 - 知乎 - 知乎专栏
同型对照（Isotype Control），是指与使用的流式抗体具有相同种属来源、亚型、荧光标记物、使用剂量和浓度，但对目标靶点无特异性结合的抗体。 同型对照通常用来消除抗体与抗原的非特异性结合…
The distribution and functions of immunoglobulin isotypes
Each human immuno-globulin isotype has specialized functions and a unique distribution. The major effector functions of each isotype (+ + +) are shaded in dark red, whereas lesser functions (+ +) are shown in dark pink, and very minor functions (+) in (more...)
Isotypes, Allotypes, and Idiotypes • Microbe Online
Allotypes in human. Allotypes have been characterized for all four IgG subclasses, IgA2 subclass, and Kappa light chain. They are designated by the class and subclass followed by the allele number. Gamma-chain allotypes (also known as Gm markers): So far at least 25 different Gm allotypes have been identified e.g. G1m(1), G2m(23), G3m (11), G4m ...
Antibody Isotypes & Subtypes | Absolute Antibody
In mammals, antibodies are classified into five main classes or isotypes – IgA, IgD, IgE, IgG and IgM. They are classed according to the heavy chain they contain – alpha, delta, epsilon, gamma or mu respectively. These differ in the sequence and number of constant domains, hinge structure and the valency of the antibody.
Antibody Isotypes for Tumor Immunotherapy - PMC
The great majority of currently approved antibodies in tumor therapy are of human IgG1 isotype. IgG2 and IgG4 isotypes are increasingly used when non-Fc-mediated effector functions are thought to be the predominant mode of action.
B cells defined by immunoglobulin isotypes - PMC
In humans, the crystallizable fragment (Fc) can be one of five isotypes (Fig. 1), each with distinct structural features that confer different effector functions.
Isotype selection for antibody‐based cancer therapy - PMC
Human antibodies can be classified into five main isotypes – immunoglobulin (Ig)G, IgA, IgM, IgE and IgD, with IgG and IgA being further divided into the subclasses IgG1, IgG2, IgG3, IgG4, and IgA1 and IgA2, respectively. Overall structural organization of an …
Immunoglobulin Isotypes: Structure, Function, and Genetics
Immunoglobulin (Ig) classes (in mammals, IgM, IgA, IgD, IgG, IgE) are defined by the isotypes of heavy (H) chains (µ, α, δ, γ, and ε). Each isotype is in turn distinguished by unique structures in its constant region domains. These different structures confer distinctive functions on the Ig classes.
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