Phosphoproteomics reveals rewiring of the insulin signaling
2023年2月18日 · Protein phosphorylation is central to the adipocyte insulin response, but how adipocyte signaling networks are dysregulated upon insulin resistance is unknown. Here we employ...
The Insulin Receptor and Its Signal Transduction Network
2016年4月27日 · A multitude of mechanisms are in place to attenuate or terminate the signal induced by insulin, both at the receptor and post-receptor level (82). The insulin receptor and IRS proteins are negatively regulated by ligand-induced downregulation, by tyrosine protein phosphatases and by serine phosphorylation.
Insulin receptor - Wikipedia
The insulin receptor is a type of tyrosine kinase receptor, in which the binding of an agonistic ligand triggers autophosphorylation of the tyrosine residues, with each subunit phosphorylating its partner.
Biochemical and cellular properties of insulin receptor signalling
2017年10月4日 · The three major biochemical steps in insulin signalling are: tyrosine phosphorylation of the receptor and its direct substrates; activation of the lipid kinase, PI3K; and activation of...
Insulin receptor endocytosis in the pathophysiology of insulin ...
2020年6月23日 · Insulin induces insulin receptor degradation in the liver through EphB4. Article 21 September 2022. ZFYVE28 mediates insulin resistance by promoting phosphorylated insulin receptor...
Comprehensive insulin receptor phosphorylation dynamics profiled …
2021年11月26日 · Insulin receptor (IR) phosphorylation is critical for the assessment of the extent of IR agonism and nuances in the downstream signaling cascade. A thorough identification and monitoring of the phosphorylation events is important for understanding the process of insulin signaling transduction and regulation.
The insulin receptor: structure, function, and signaling
In all cases but the insulin receptor (and 2 closely related receptors), these dimers are noncovalent, but insulin receptors are covalently maintained as functional dimers by disulfide bonds. The initial response to the ligand is receptor autophosphorylation for …
Phosphorylation of IRS proteins, insulin action, and insulin resistance
Phosphorylation of insulin receptor substrate (IRS) proteins on serine residues has emerged as a key step in these control processes under both physiological and pathological conditions. The list of IRS kinases implicated in the development of insulin resistance is growing rapidly, concomitant with the list of potential Ser/Thr phosphorylation ...
Phosphorylation of Insulin Receptor Substrate-1 (IRS-1) by …
Incubation of cells with insulin leads to a transient rise in Tyr phosphorylation of insulin receptor substrate (IRS) proteins, accompanied by elevation in their Ser(P)/Thr(P) content and their dissociation from the insulin receptor (IR).
Molecular Mechanisms of Insulin Resistance: Serine Phosphorylation of ...
2006年8月1日 · Inhibition of the metabolic insulin signaling. IRS-1 is phosphorylated by the tyrosine kinase of the insulin receptor in response to insulin binding. Protein/lipid kinase, PI 3-kinase, binds to the specific MYMX motifs of IRS-1, containing phosphorylated tyrosine residues.