HMGB1 Expression Levels Correlate with Response to …
High-mobility group box 1 protein (HMGB1) is subject to exportin 1 (XPO1)-dependent nuclear export, and it is involved in functions implicated in resistance to immunotherapy. We investigated whether HMGB1 mRNA expression was associated with response to immune checkpoint inhibitors (ICI) in non-small cell lung cancer (NSCLC).
The function and mechanism of HMGB1 in lung cancer and its …
HMGB1 has been demonstrated to induce tumorigenesis, metastasis and chemotherapeutic responses in lung cancer. HMGB1 receptors involved in lung cancer progression include RAGE and TLRs. The effects of HMGB1 are executed via various signaling pathways, including PI3K/Akt, NF-κB (p65) and MAPK (ERK1/2, p38). A schematic illustration of HMGB1 ...
HMGB1 enhances epithelial permeability via p63/TGF-β signaling in lung …
HMGB1 impairs airway epithelial barrier function through activation of the receptor for advanced glycation end-products (RAGE)/ERK pathway. 6 The RAGE pathway is involved in lung epithelial wound repair via enhanced cell migration and cell proliferation. 7 TNF-α stimulates the production and secretion of HMGB1 in cultured airway epithelial ...
A narrative review on lung injury: mechanisms, biomarkers, and ...
2024年10月31日 · Lung injury is closely associated with the heterogeneity, severity, mortality, and prognosis of various respiratory diseases. ... LPS exposure upregulates RAGE and HMGB1 in mouse models. Lower sRAGE levels in ILD and IPF suggest AT1 cell loss in these diseases, emphasizing sRAGE as a disease-specific marker for AT1 cell injury [52, 53].
High Mobility Group Box Protein 1 Serves as a Potential Prognostic ...
2018年4月19日 · 3.2. The Relationship between the Expression of HMGB1 in Lung Cancer Tissue and Clinical Pathological Parameters. HMGB1 expression level was associated with the clinical pathological characteristics of the patients with lung cancer, such as T stage (P = 0.027) and lymph node metastasis of the tumor (P = 0.019), and …
Lung-derived HMGB1 is detrimental for vascular remodeling of ...
2020年8月27日 · Nature Communications - Lung damage increases abdominal aortic aneurysm (AAA) incidence, but the mechanism was unclear. Here, the authors show that injured lungs leak HMGB1, increasing RIPK3...
Role of HMGB1 and its associated signaling pathways in human ...
2023年9月26日 · An in vitro study in human lung epithelial cells showed that HMGB1 promotes angiotensin-converting enzyme 2 (ACE2) expression, a receptor for SARS-CoV-2, through binding to the Receptor for Advanced Glycosylation End-product (RAGE) [29].
Emerging role of HMGB1 in lung diseases: friend or foe
2016年12月31日 · Accumulating data have demonstrated that HMGB1 is crucially implicated in lung diseases and acts as independent biomarker and therapeutic target for related lung diseases. This review provides an overview of updated understanding of HMGB1 structure, release styles, receptors and function.
The function and mechanism of HMGB1 in lung cancer and its ... - PubMed
HMGB1 may induce tumorigenesis, metastasis and chemotherapy resistance in lung cancer. Overall, it is evident that HMGB1 serves an important role in the development and progression of lung cancer, and this review warrants further investigation …
Autophagic secretion of HMGB1 from cancer-associated ... - Nature
2021年9月22日 · High mobility group box 1 (HMGB1) secreted by CAFs mediated CAFs’ effect on lung cancer cell invasion, demonstrated by using recombinant HMGB1, HMGB1 neutralizing antibody, and HMGB1...