二氢乳清酸脱氢酶的结构特征和催化循环研究进展
二氢乳清酸脱氢酶(Dihydroorotate dehydrogenase，DHODH)是一种含铁的黄素依赖的线粒体酶，它主要存在于线粒体内膜上，是嘧啶核苷酸从头合成途径第4步的关键酶，它能催化氧化二氢乳清酸，使其脱氢转变为乳清酸。
Dihydroorotate dehydrogenase - Wikipedia
Dihydroorotate dehydrogenase (DHODH) is an enzyme that in humans is encoded by the DHODH gene on chromosome 16. The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de …
Discovery of potential natural dihydroorotate dehydrogenase …
2022年11月9日 · Dihydroorotate dehydrogenase (DHODH), situated in the mitochondrial inner membrane, is an iron containing flavin-subordinate enzyme and assumes an essential part in the de novo synthesis of ...
Dihydroorotate Dehydrogenase - an overview - ScienceDirect
Dihydroorotate dehydrogenase (DHODH) is the fourth enzyme of the pyrimidine de novo pathway and it catalyzes the conversion of dihydroorotate to orotate. In most eukaryotes, DHODH is localized in mitochondria and the electrons are transferred directly to …
Revisiting the role of dihydroorotate dehydrogenase as a
One enzyme essential for the de novo biosynthesis of pyrimidine-based nucleotides is dihydroorotate dehydrogenase (DHODH), a known therapeutic target for multiple diseases. Brequinar, leflunomide, and teriflunomide, all of which are potent DHODH inhibitors, have been clinically evaluated but failed to receive FDA approval for the treatment of ...
DHODH-mediated ferroptosis defence is a targetable ... - Nature
2021年5月12日 · Supplementation with dihydroorotate or orotate—the substrate and product of dihydroorotate dehydrogenase (DHODH)—attenuates or potentiates ferroptosis induced by inhibition of GPX4 ...
DHODH inhibition represents a therapeutic strategy and improves ...
2024年3月13日 · Here, we showed that dihydroorotate dehydrogenase (DHODH), an enzyme crucial in the pyrimidine biosynthesis pathway, is a promising therapeutic target for CRPC.
The dihydroorotate dehydrogenases: Past and present - PubMed
2017年10月15日 · The flavoenzyme dihydroorotate dehydrogenase catalyzes the stereoselective oxidation of (S)-dihydroorotate to orotate in the fourth of the six conserved enzymatic reactions involved in the de novo pyrimidine biosynthetic pathway.
The dihydroorotate dehydrogenases: Past and present
2017年10月15日 · The flavoenzyme dihydroorotate dehydrogenase catalyzes the stereoselective oxidation of (S)-dihydroorotate to orotate in the fourth of the six conserved enzymatic reactions involved in the de novo pyrimidine biosynthetic pathway. Inhibition of pyrimidine metabolism by selectively targeting DHODHs has been exploited in the development of new ...
The pathway to pyrimidines: The essential focus on dihydroorotate ...
The intervening enzyme dihydroorotate dehydrogenase (DHODH) is located in the mitochondrion with access to the ubiquinone pool, thus ensuring efficient removal of redox equivalents through the constitutive activity of the respiratory chain, also a mechanism through which the input of 2 ATP for carbamylphosphate synthesis is balanced by Oxphos.