Chromosome instability - Wikipedia
Chromosomal instability (CIN) is a type of genomic instability in which chromosomes are unstable, such that either whole chromosomes or parts of chromosomes are duplicated or deleted. More specifically, CIN refers to the increase in rate of addition or loss of entire chromosomes or sections of them. [ 1 ]
The two sides of chromosomal instability: drivers and brakes
2024年3月29日 · Chromosomal instability (CIN) is a hallmark of cancer and is associated with tumor cell malignancy. CIN triggers a chain reaction in cells leading to chromosomal abnormalities, including...
Structural Chromosome Instability: Types, Origins, …
Chromosome instability (CIN) is characterized by an increased accumulation of numerical and structural changes in chromosomes and is a common feature of solid tumors and some hematological malignancies. CIN has been extensively linked to tumorigenesis, cancer progression, and tumor resistance.
Chromosomal Instability - an overview | ScienceDirect Topics
Chromosomal instability (CIN) is the most common type of genomic instability characterized by the number of chromosomal aberrations, sub chromosomal amplification, and loss of heterozygosity, amounting to almost 60%–70% of colorectal cancers, more commonly in the distal cancers (cancers confined to the sigmoid and descending colon) [26 ...
Chromosome Instability Syndromes - StatPearls - NCBI Bookshelf
2022年9月19日 · Chromosomal instability syndromes are a group of rare, inherited disorders characterized by a predisposition to chromosomal instability and breakage, either spontaneously or in response to deoxyribonucleic acid (DNA)-damaging agents.
Mechanisms of Chromosomal Instability - PMC - PubMed Central …
Most solid tumors are aneuploid and many mis-segregate chromosomes at very high rates in a phenomenon termed chromosomal instability (CIN). Aneuploidy is a state in which the number of chromosomes in a cell or organism deviates from multiples of …
The multifaceted role of chromosomal instability in cancer and its ...
Chromosomal instability (CIN) is a hallmark of human cancer and it is associated with poor prognosis, metastasis, and therapeutic resistance. CIN results from errors in chromosome segregation during mitosis leading to structural and numerical ...
Chromosome Instability - an overview | ScienceDirect Topics
In particular, chromosome instability (CIN) is a common form of genome instability defined as an increase in the rate at which whole chromosomes (numerical CIN) or large chromosome fragments (structural CIN) are gained or lost [3].
Structural Chromosome Instability: Types, Origins, …
2021年6月19日 · Chromosomal instability (CIN) refers to an increased rate of acquisition of numerical and structural changes in chromosomes and is considered an enabling characteristic of tumors. Given its role as a facilitator of genomic changes, CIN is increasingly being considered as a possible therapeutic targe …
Chromosomal instability as a driver of cancer progression
2024年7月29日 · Chromosomal instability (CIN) refers to an increased propensity of cells to acquire structural and numerical chromosomal abnormalities during cell division, which contributes to tumour genetic...
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