What is the Cell Cycle and How Is It Related to Cancer?
2023年5月16日 · The cell cycle and cancer. Slip-ups or errors in any stage of the cell cycle — especially during the replication of DNA or allocation of DNA to the daughter cells — can set cells on a course for cancer.
Genetics, Cancer Cell Cycle Phases - StatPearls - NCBI Bookshelf
2023年8月14日 · Overall, the cell cycle has many regulatory steps that are crucial to maintaining homeostasis inside of the cells during the replication of DNA and the division of cells. Mutation inside specific genes can lead to the loss of balance inside the cells, thus resulting in …
Cell cycle control in cancer - Nature Reviews Molecular Cell Biology
2021年9月10日 · This Review discusses our current understanding of cell cycle regulation, the functions of cell cycle checkpoints and how disruption of these finely tuned mechanisms is associated with...
Khan Academy
Explore the mechanisms of cancer development and its impact on cell cycle regulation.
2021年9月10日 · vides a better understanding of cell cycle control in cancer and reveals particular dependency on specific checkpoint functions, creating new therapeutic opportunities.
Cell cycle on the crossroad of tumorigenesis and cancer therapy
2021年7月22日 · A growing body of evidence indicates that the cell cycle regulatory pathway integrates into other hallmarks of cancer, including metabolism remodeling and immune escape. Thus, therapies against cell cycle machinery components can not only repress the division of cancer cells, but also reverse cancer metabolism and restore cancer immune ...
Cell cycle proteins as promising targets in cancer therapy
2017年1月27日 · Many cell cycle proteins are overexpressed or overactive in human cancers, in particular, D-type and E-type cyclins, cyclin-dependent kinases (CDK4, CDK6 and CDK2), Polo-like kinase 1...
The cell cycle and cancer - PNAS
1997年4月1日 · By what molecular pathway does loss of cell cycle regulation in an organism lead to cancer? What genetic changes can cooperate to accomplish the cancer cell’s escape from the normal balance of cell growth?
The pathophysiology of the cell cycle in cancer and treatment ...
2023年11月1日 · Cell cycle control is crucial in preventing the development of cancer. The cell cycle is a tightly regulated process that ensures the proper replication and division of cells. It is controlled by a complex network of proteins and regulatory pathways that ensure the integrity of …
Cell cycle control in cancer - PubMed
Checkpoints can delay cell cycle progression or, in response to irreparable DNA damage, induce cell cycle exit or cell death. Cancer-associated mutations that perturb cell cycle control allow continuous cell division chiefly by compromising the ability of cells to exit the cell cycle.