Brucella – Virulence Factors, Pathogenesis and Treatment
Brucella, can modify immune response in host cells; it has an affinity to the cells of specific tissues, e.g. placental trophoblast in fetal lung, pregnant females or reproductive system (de Figureido et al., 2015). Brucellosis causes enlargement of lymph …
Immune Response to Mucosal Brucella Infection - PMC
2019年8月20日 · In this review we will discuss the concepts of innate mucosal immunity involved in mucosal protection against Brucella infection. The mechanisms used by Brucella spp. to evade the elements of oral, intestinal, and repiratory mucosal immunity will also be analyzed.
Pathogenesis and immune response in Brucella infection acquired …
2020年10月1日 · The pathogen disseminates systemically from the lungs to infect peripheral organs. In this review we summarize the existing data on the pathogenesis of inhalational Brucella infection, the pulmonary immune response to the pathogen, and potential strategies for inducing protective lung immunity.
Evasion of host defense by Brucella - ScienceDirect
2024年2月1日 · Brucella employs various mechanisms to evade and undermine the innate and adaptive immune responses of the host through modulating the activation of pattern recognition receptors (PRRs), inflammatory responses, or the activation of immune cells like dendritic cells (DCs) to inhibit antigen presentation. Moreover, it regulates multiple cellular ...
Single‐cell landscape revealed immune characteristics associated …
Single-cell RNA sequencing of 290,369 cells from 29 brucellosis patients and 6 healthy donors reveals distinct immune profiles across acute, subacute, and chronic phases of the disease. Acute patients experience a cytokine storm triggered by classical monocytes, potentially mediated by the S100A8/A9-TLR4-MyD88 signaling pathway.
Pathogenesis and Immunobiology of Brucellosis: Review of Brucella…
2015年6月1日 · Brucellae display strong tissue tropism for lymphoreticular and reproductive systems with an intracellular lifestyle that limits exposure to innate and adaptive immune responses, sequesters the organism from the effects of antibiotics, and drives clinical disease manifestations and pathology.
Establishment of Chronic Infection: Brucella's Stealth Strategy
2016年3月15日 · At early process of infectious pathogenesis, Brucella modulate the immune response mechanism of host to quickly translocate through mucosal immune barrier and is endocytosed by mucosal macrophages and DCs. Stealthy brucellae use different type of strategies to establish and maintain chronic infection by fusion of type IV secretary system ...
Host Immune Responses and Pathogenesis to Brucella spp. Infection
2021年3月3日 · Brucellosis, caused by the facultative intracellular bacteria <i>Brucella</i> species, is one the most prevalent zoonoses worldwide [...].
Pathogenesis and immune response in Brucella infection
In this review we summarize the existing data on the pathogenesis of inhalational Brucella infection, the pulmonary immune response to the pathogen, and potential strategies for inducing protective lung immunity.
Single-cell landscape revealed immune characteristics ... - PubMed
2024年7月23日 · A comprehensive immune landscape for Brucella infection is crucial for developing new treatments for brucellosis. Here, we utilized single-cell RNA sequencing (scRNA-seq) of 290,369 cells from 35 individuals, including 29 brucellosis patients from acute ( n = 10), sub-acute ( n = …