β-淀粉样蛋白 - 百度百科
β 淀粉样蛋白 ( amyloid-β，Aβ) 是由 淀粉样前体蛋白 ( amyloid precursor protein，APP) 经 β-和 γ- 分泌酶 的 蛋白水解作用 而产生的含有 39～43 个 氨基酸 的多肽。 它可由多种细胞产生，循环于血液、 脑脊液 和脑 间质液 中，大多与 伴侣蛋白 分子结合，少数以 游离状态 存在。 人体内 Aβ最常见的亚型是 Aβ1～ 40 和 Aβ1～ 42。 在人脑脊液和血中，Aβ1～ 40分别比 Aβ1～ 42的含量水平高 10 倍和 1． 5倍，Aβ1～ 42具有更强的毒性，且更容易聚集，从而形成Aβ 沉淀的核心，引发神 …
Amyloid beta - Wikipedia
Amyloid beta (Aβ, Abeta or beta-amyloid) denotes peptides of 36–43 amino acids that are the main component of the amyloid plaques found in the brains of people with Alzheimer's disease. [2] The peptides derive from the amyloid-beta precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ in a cholesterol ...
The Amyloid-β Pathway in Alzheimer’s Disease - Nature
2021年8月30日 · The Aβ is a 4 kDa fragment of the amyloid precursor protein (APP), a larger precursor molecule widely produced by brain neurons, vascular and blood cells (including platelets), and, to a lesser...
Amyloid beta: structure, biology and structure-based …
2017年7月17日 · In this paper, we review the structures, biological functions, and neurotoxicity role of Aβ. We also discuss the potential receptors that interact with Aβ and mediate Aβ intake, clearance, and...
Amyloid Beta Peptide - StatPearls - NCBI Bookshelf
2023年8月28日 · Amyloid beta peptide is a 42-amino acid peptide and derives from the precursor protein, amyloid beta precursor protein (APP). The amyloid beta precursor protein is a transmembrane glycoprotein that spans the membrane once. The gene for amyloid beta precursor protein is on chromosome 21.
Amyloid beta: structure, biology and structure-based therapeutic ...
Amyloid beta peptide (Aβ) is produced through the proteolytic processing of a transmembrane protein, amyloid precursor protein (APP), by β- and γ-secretases. Aβ accumulation in the brain is proposed to be an early toxic event in the pathogenesis of ...
β-Amyloid: the key peptide in the pathogenesis of Alzheimer’s …
2015年9月30日 · Aβ is generated from amyloid precursor protein through sequential cleavage of β- and γ-secretases while Aβ removal is dependent on the proteolysis and lysosome degradation system. Here, we overviewed the biogenesis and toxicity of Aβ as well as the regulation of Aβ production and clearance.
Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic …
The amyloid β protein has been identified as an important component of both cerebrovascular amyloid and amyloid plaques of Alzheimer's disease and Down syndrome. A complementary DNA for the β protein suggests that it derives from a larger protein expressed in a variety of tissues.
What is the Physiological Function of Amyloid-Beta Protein?
2019年2月8日 · Most of the studies of amyloid-beta (Aβ) have concentrated on the pathological effects of high levels of the protein in causing cognitive impairment and Alzheimer’s disease (1). There is some evidence that the Amyloid Precursor Protein (APP) has a physiological trophic function on the central nervous system (2).
Amyloid β-based therapy for Alzheimer’s disease: challenges
2023年6月30日 · Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer’s disease (AD), and its accumulation has been considered as the molecular driver of Alzheimer’s pathogenesis and ...
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