AmyLoad: website dedicated to amyloidogenic protein fragments
2015年6月17日 · Sequences presented on the AmyLoad website are listed in a table with columns indicating protein name, fragment name, amino acid sequence and the information about amyloidogenicity. Additional details are separately presented for each fragment, such as an examination method, source dataset references (see Section 2), references to relevant ...
The Amyloid-β Pathway in Alzheimer’s Disease - Nature
2021年8月30日 · The Aβ is a 4 kDa fragment of the amyloid precursor protein (APP), a larger precursor molecule widely produced by brain neurons, vascular and blood cells (including platelets), and, to a lesser...
Amyloid beta: structure, biology and structure-based therapeutic ...
Amyloid beta peptide (Aβ) is produced through the proteolytic processing of a transmembrane protein, amyloid precursor protein (APP), by β- and γ-secretases. Aβ accumulation in the brain is proposed to be an early toxic event in the pathogenesis of ...
Amyloid beta: structure, biology and structure-based …
2017年7月17日 · In this paper, we review the structures, biological functions, and neurotoxicity role of Aβ. We also discuss the potential receptors that interact with Aβ and mediate Aβ intake, clearance, and...
The amyloid precursor protein and its derived fragments
2024年5月28日 · The contribution of the amyloid precursor protein (APP) and its derived fragments to the mitochondrial transport machinery alterations in AD have not been investigated before.
Roles of amyloid precursor protein and its fragments in …
2003年5月1日 · Amyloid-β precursor protein (APP) is a membrane-spanning protein with a large extracellular domain and a much smaller intracellular domain. It is the source of the amyloid-β (Aβ) peptide found in neuritic plaques of Alzheimer’s disease (AD) patients.
Spike Protein Fragments Promote Alzheimer’s Amyloidogenesis
2023年8月16日 · Here we first identified the amyloidogenic potential of 1058 HGVVFLHVTYV 1068, a short fragment of the spike protein of SARS-CoV-2 coronavirus.
Spike Protein Fragments Promote Alzheimer’s Amyloidogenesis
2023年8月8日 · Here we first identified the amyloidogenic potential of 1058 HGVVFLHVTYV 1068, a short fragment of the spike protein of SARS-CoV-2 coronavirus.
Amyloid Precursor Protein Processing and Alzheimer’s Disease
Sequential cleavage of the amyloid precursor protein (APP) occurs by two pathways. (a) The APP family of proteins has large, biologically active, N-terminal ectodomains as well as a shorter C-terminus that contains a crucial Tyrosine–Glutamic Acid-Asparagine-Proline-Threonine-Tyrosine (YENPTY) protein-sorting domain to which the adaptor proteins X11 and Fe65 bind.
The amyloid precursor protein and its derived fragments …
2024年5月28日 · Mitochondria dysfunctions and mitophagy failure have been associated with several Alzheimer's disease (AD) related molecular actors including amyloid beta (Aβ) and recently the amyloid precursor protein-C terminal fragments (APP-CTFs). The efficacy of the mitophagy process in neurons relies on regul …
- 某些结果已被删除