8-Oxoguanine - Wikipedia
8-Oxoguanine (8-hydroxyguanine, 8-oxo-Gua, or OH 8 Gua) is one of the most common DNA lesions resulting from reactive oxygen species [2] modifying guanine, and can result in a mismatched pairing with adenine resulting in G to T and C to A substitutions in the genome. [3] In humans, it is primarily repaired by DNA glycosylase OGG1.
8-Oxoguanine: from oxidative damage to epigenetic and ... - Nature
2022年10月21日 · Emerging evidence suggests the modified base 8-oxoguanine, created when damaging chemicals called reactive oxygen species interact with DNA and RNA, has more extensive effects on cell function ...
OGG1，DNA氧化损伤修复者 - 知乎 - 知乎专栏
OGG1，DNA氧化损伤修复者. 活性氧自由基ROS造成的DNA损伤是肿瘤发生和发展的关键因素，DNA分子的主要氧化产物8-氧-鸟嘌呤（8-oxo-7,8-dihydroguanine；8-oxo-Gua）被认为是DNA氧化损伤的生物标志物。. 8-oxo-Gua具有高度致突变性，在通过DNA聚合酶进行复制时，产生G：C—T：A ...
8-Oxoguanine: from oxidative damage to epigenetic and ...
Here, we review the functions of 8-oxoguanine as an oxidative modification in DNA (8-oxo-dG) and RNA (o 8 G), describing oxidative damage, which necessitates repair or quality control, and regulatory mechanisms for redox-mediated gene expression at the transcriptional and posttranscriptional levels.
8-Oxoguanine - an overview | ScienceDirect Topics
8-Oxoguanine is a widely studied and prevalent oxidized base in DNA that is formed by the oxidation of guanine at C8. It serves as a biomarker for oxidative DNA damage and is often used to study the repair of such damage. 8-Oxoguanine can adopt different conformational structures and has mutagenic properties, but it does not significantly ...
8-Oxoguanine accumulation in mitochondrial DNA causes
2016年2月25日 · Oxidative stress and mitochondrial dysfunction are implicated in aging-related neurodegenerative disorders. 8-Oxoguanine (8-oxoG), a common oxidised base lesion, is often highly accumulated in...
Here, we review the functions of 8-oxoguanine as an oxidative modification in DNA (8-oxo-dG) and RNA (o 8 G), describing oxidative damage, which necessitates repair or quality control,
8-Oxoguanine: from oxidative damage to epigenetic and
2022年10月21日 · Here, we address the production, regulation, and function of 8-oxo-dG and o 8 G under oxidative stress. Primarily, we focus on the epigenetic and epitranscriptional roles of 8-oxoguanine, which highlights the significance of oxidative modification in redox-mediated control of gene expression.
Roles for the 8-Oxoguanine DNA Repair System in Protecting …
Generally, the repair of small and often non-helix-distorting DNA base lesions, such as 8-oxoG, is carried out by the base excision repair (BER) pathway, which utilizes several highly conserved proteins involved in the essential steps of damage recognition and DNA restoration.
Dynamics of 8-Oxoguanine in DNA: Decisive Effects of Base …
2023年3月2日 · 8-Oxo-7,8-dihydroguanine (oxoG), an abundant DNA lesion, can mispair with adenine and induce mutations. To prevent this, cells possess DNA repair glycosylases that excise either oxoG from oxoG:C pairs (bacterial Fpg, human OGG1) or A from oxoG:A mispairs (bacterial MutY, human MUTYH).
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