Complex roles of cAMP-PKA-CREB signaling in cancer
2020年11月24日 · Cyclic adenosine monophosphate (cAMP) is the first discovered second messenger, which plays pivotal roles in cell signaling, and regulates many physiological and pathological processes. cAMP can regulate the transcription of various target genes, mainly through protein kinase A (PKA) and its downstr ….
CREB：cAMP反应元件结合蛋白 - 知乎 - 知乎专栏
cAMP反应元件结合蛋白（cyclic-AMP response binding protein，CREB）由341个氨基酸残基构成，是富含亮氨酸拉链结构（bZIP）的超家族成员。. CREB二级结构包含两个功能区：. C端是富含碱性氨基酸的DNA结合区，含bZIP，与DNA亲和力较强，又称DNA结合域；. N端是富含酸性氨基 …
cAMP信号通路（主要基因/通路基因分类/信号通路图） - 知乎
2024年1月3日 · cAMP直接作用于三个主要靶标：蛋白激酶A（PKA）、被cAMP激活的交换蛋白（Epac）和环核苷酸门控离子通道（CNGCs）。PKA通过磷酸化对多个细胞底物进行调节，包括转录因子、离子通道、转运蛋白、交换蛋白、细胞内Ca2 +处理蛋白和收缩机制。
第一个发现的细胞内第二信号——cAMP信号通路（下）_调节
2020年11月12日 · 在海马神经元(Hippocampal neuron)中，PKA可以通过Rap1激活的MAPK途径间接激活或者直接激活转录因子CREB(cAMP-response element binding protein，环磷腺苷效应元件结合蛋白)，启动转录的下游基因包括BDNF、fos、jun。
cAMP信号通路 - 百度百科
环核苷酸系统. 又称 PKA系统 (protein kinase A system, PKA)，是环核苷酸系统的一种。. 在这个系统中，细胞外信号与相应受体结合，通过调节细胞内 第二信使 cAMP 的水平而引起反应的 信号通路。. 信号分子 通常是激素，对cAMP水平的调节，是靠 腺苷酸环化酶 进行的 ...
cAMP Signaling in Cancer: A PKA-CREB and EPAC-Centric Approach
2022年6月24日 · Tumor growth is associated with increased CREB expression and activation. PKA can be used as both an onco-drug target and a biomarker to find, identify, and stage tumors. Exploring cAMP effectors and their downstream pathways in cancer has become easier using exchange protein directly activated by cAMP (EPAC) modulators.
Tolerance to sustained activation of the cAMP/Creb pathway
2018年8月28日 · Evidence for elevated and persistent signalling through the cAMP/PKA axis in OS has come from mouse genetic models, including those we have developed 6,7,8,9, as well as from mutational...
Transcriptional regulation by the phosphorylation-dependent factor CREB …
2001年8月1日 · Differential regulation of target genes by cAMP, through CREB, is achieved by varying the sequence composition and placement of the CRE on the promoter.
cAMP Signaling in Cancer: A PKA-CREB and EPAC-Centric Approach
There may be an impact on gene transcription from protein kinase A (PKA) as well as its downstream effectors, such as cAMP response element-binding protein (CREB). The position of CREB downstream of numerous growth signaling pathways implies its …
The cAMP signalling pathway activates CREB through PKA
2005年11月1日 · Cyclic adenosine 3′,5′-monophosphate (cAMP) was originally shown to induce gene transcription through activation of cAMP-dependent protein kinase (PKA), and subsequent phosphorylation of the transcription factor cAMP response element …