Ursodeoxycholic Acid - StatPearls - NCBI Bookshelf
2023年2月12日 · Ursodeoxycholic acid is a medication used to manage and treat cholestatic liver disease. This activity reviews the indications, mechanism of action, and contraindications for …
Ursodeoxycholic acid - Wikipedia
Ursodeoxycholic acid (UDCA), also known as ursodiol, is a secondary bile acid, produced in humans and most other species from metabolism by intestinal bacteria.
Ursodeoxycholic acid: Uses, Interactions, Mechanism of Action ...
Ursodeoxycholic acid (UDCA) is a secondary bile acid with cytoprotectant, immunomodulating, and choleretic effects. It reduces the cholesterol fraction of biliary lipids. 1. Endogenous …
Ursodiol: Dosage, Mechanism/Onset of Action, Half-Life
2020年2月17日 · Includes Ursodiol indications, dosage/administration, pharmacology, mechanism/onset/duration of action, half-life, dosage forms, interactions, warnings, adverse …
Drug Insight: mechanisms and sites of action of ... - Nature
2006年6月1日 · Ursodeoxycholic acid (UDCA) exerts anticholestatic effects in various cholestatic disorders. Several potential mechanisms and sites of action of UDCA have been unraveled in …
Ursodiol (Ursodeoxycholic Acid) - LiverTox - NCBI Bookshelf
2017年9月25日 · Ursodeoxycholic acid or ursodiol is a naturally occurring bile acid that is used dissolve cholesterol gall stones and to treat cholestatic forms of liver diseases including …
Mechanisms of action and therapeutic efficacy of ursodeoxycholic …
Multiple mechanisms of action of UDCA have been described aiming at one or more of the pathogenetic processes of cholestatic liver diseases: (1) protection of injured cholangiocytes …
Bile acids are acidic steroids that are synthesized from cholesterol within the hepatocytes. UDCA represents a hydrophilic dihydroxy (i.e. 3a, 7b-dihydroxy-5b-cholan- 24-oic acid) bile acid (Fig. …
Ursodeoxycholic acid in cholestatic liver disease: mechanisms of …
In primary biliary cirrhosis, UDCA (13-15 mg/kg/d) improves serum liver chemistries, may delay disease progression to severe fibrosis or cirrhosis, and may prolong transplant-free survival.
Ursodeoxycholic acid: Mechanism of action and novel clinical ...
2007年11月23日 · Suggested mechanisms include the improvement of bile acid transport and/or detoxification, cytoprotection, and anti-apoptotic effects. In this review, we summarize the …
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