Uric acid - Wikipedia
Uric acid is a heterocyclic compound of carbon, nitrogen, oxygen, and hydrogen with the formula C 5 H 4 N 4 O 3. It forms ions and salts known as urates and acid urates, such as ammonium acid urate. Uric acid is a product of the metabolic breakdown of purine nucleotides, and it is a normal component of urine. [1]
Hyperuricemia and its related diseases: mechanisms and ... - Nature
2024年8月28日 · Hyperuricemia, characterized by elevated levels of serum uric acid (SUA), is linked to a spectrum of commodities such as gout, cardiovascular diseases, renal disorders,...
Regulation of uric acid metabolism and excretion - ScienceDirect
2016年6月15日 · In humans the final compound of purines catabolism is uric acid. All other mammals possess the enzyme uricase that converts uric acid to allantoin that is easily eliminated through urine. Overproduction of uric acid, generated from the metabolism of purines, has been proven to play emerging roles in human disease.
Regulation of uric acid metabolism and excretion - PubMed
2016年6月15日 · In humans the final compound of purines catabolism is uric acid. All other mammals possess the enzyme uricase that converts uric acid to allantoin that is easily eliminated through urine. Overproduction of uric acid, generated from the metabolism of purines, has been proven to play emerging roles in human disease.
Signaling pathways in uric acid homeostasis and gout: From …
2024年5月10日 · open access. Highlights. •. Overproduction, and/or renal underexcretion, and/or gut underexcretion of urate can cause hyperuricemia. •. MSU crystals can induce gout through post-translational processing of pro-IL-1β. •. Modern medicine with a single target is difficult to exert long-term positive effects, and even has severe adverse effects. •.
Physiological functions and pathogenic potential of uric acid: …
The enzyme uricase (urate oxidase) can metabolize uric acid to highly soluble 5-hydroxyisourate that is further degraded to allantoic acid and ammonia, easily excreted by the kidneys.
Uric Acid - Clinical Methods - NCBI Bookshelf - National Center …
Xanthine oxidase, the enzyme responsible for conversion of oxypurines to uric acid, is found in abundance in the liver and the mucosa of the small intestine. Most dietary nucleic acids are ingested in the form of nucleoproteins and can be metabolized to uric …
Regulation of uric acid metabolism and excretion
2016年6月15日 · The balance of uric acid formation and excretion is driven by several enzymatic pathways which occur via different genetically-defined isoforms being also highly regulated by pathophysiological determinants including metabolic products and free radical species.
Completing the uric acid degradation pathway through ... - Nature
2006年2月5日 · To find the missing enzymes in the biological conversion of uric acid to allantoin, we sought proteins with a functional link to urate oxidase, the first enzyme of the pathway. Functional...
Uric acid in health and disease: From physiological functions to ...
2024年4月1日 · Owing to renal reabsorption and the loss of uricase activity, uric acid (UA) is strictly maintained at a higher physiological level in humans than in other mammals, which provides a survival advantage during evolution but increases susceptibility to …