Thymidylate synthase - Wikipedia
Thymidylate synthase (TS) (EC 2.1.1.45) [5] is an enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP). Thymidine is one of the nucleotides in DNA.
Folate-Dependent Thymidylate-Forming Enzymes: Parallels …
Enzymatic methylation of the C5 atom of uridyl to form (ribo)thymidyl occurs during the metabolism of DNA and RNA in all organisms. The first enzyme found to catalyze this fundamental reaction was thymidylate synthase ThyA that uses methylene tetrahydrofolate as carbon source and reducing agent to form thymidylate, an essential DNA precursor.
Thymidylate Synthase - an overview | ScienceDirect Topics
Thymidylate synthase catalyzes the synthesis of dTMP from dUMP, which may be generated through phosphorolysis of dUTP formed from UTP or from the deamination of dCTP. An alternative route involves the deamination of dCMP.
Standing the test of time: targeting thymidylate biosynthesis
2014年4月15日 · We overview the pivotal discoveries that led to the rational development of thymidylate biosynthesis as a chemotherapeutic target, and highlight the crucial contribution of these advances to ...
An unusual mechanism of thymidylate biosynthesis in organisms …
2009年4月16日 · This paper reports an example of thymidylate biosynthesis that occurs without an enzymatic nucleophile, and is found in organisms containing the thyX gene (encoding a flavin-dependent...
Thymidylate Synthase - an overview | ScienceDirect Topics
Thymidylate synthase (TS) is an enzyme present in mammalian cells which catalyzes the reductive methylation of deoxyuridylate by 5,10-methylene-5,6,7,8-tetrahydrofolic acid to form thymidylate (dTMP) and dihydrofolic acid. It is the only reaction allowing formation of dTMP in mammalian cells and is thus essential for DNA replication.
Thymidylate Synthase - an overview | ScienceDirect Topics
Thymidylate synthase is an enzyme which catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate or thymidylate) …
Diagnostic and prognostic value of thymidylate synthase …
Thymidylate synthase expression is significant relationships with clinical parameters and survival of breast cancer patients. We suggest that TYMS might be useful as a diagnostic and prognostic indicator for breast cancer.
Bacterial versus human thymidylate synthase: Kinetics and …
Thymidylate Synthase (TSase) is a highly conserved enzyme that catalyzes the production of the DNA building block thymidylate. Structurally, functionally and mechanistically, bacterial and mammalian TSases share remarkable similarities. Because of this closeness, bacterial enzymes have long been used as model systems for human TSase.
Thymidylate Synthesis - Field - Major Reference Works - Wiley …
2016年4月15日 · Thymidylate (deoxythymidine 5′-monophosphate, 5-methyluracil-2′-deoxyriboside-5′-phosphate, dTMP) (Figure 1) is an essential metabolite required for deoxyribonucleic acid (DNA) synthesis and repair. Thymidylate can be synthesised through a salvage pathway or de novo through a folate-dependent pathway.