Clinical and laboratory diagnosis of TTP: an integrated approach
2018年11月30日 · In this article, we review the epidemiology, natural history, and clinical presentation of TTP and laboratory assays for TTP including ADAMTS13 activity and inhibitor assays. We also describe an evidence-based approach to the evaluation of a patient with suspected TTP that integrates clinical and laboratory assessment.
Thrombotic thrombocytopenic purpura | Blood | American …
2017年5月25日 · Thrombotic thrombocytopenic purpura (TTP) is a rare and life-threatening thrombotic microangiopathy characterized by microangiopathic hemolytic anemia, severe thrombocytopenia, and organ ischemia linked to disseminated microvascular platelet rich-thrombi.
TTP - American Society of Hematology
This images shows the peripheral blood smear of a patient diagnosed with thrombotic thrombocytopenic purpura (TTP). The blood smear shows anemia, thrombocytopenia along with the presence of large platelets, poikilocytosis, schistocytes and increased reticulocyte count (nRBC) which ultimately are the evidences of microangiopathic hemolytic ...
Thrombotic Thrombocytopenic Purpura - Cleveland Clinic
2022年2月9日 · Thrombotic thrombocytopenic purpura (TTP) is a rare blood disorder in which thrombi (blood clots) form in small blood vessels throughout your body. These blood clots can restrict the flow of oxygen-rich blood to your organs, causing a number of life-limiting complications. Treatments include plasma therapy, medication and surgery.
Thrombotic thrombocytopenic purpura (TTP) - MyHematology
Thrombotic thrombocytopenic purpura (TTP) is a rare and life-threatening blood disorder. It is characterized by the formation of small blood clots (microthrombi) throughout the body. These microthrombi can block small blood vessels and damage organs, …
Thrombotic Thrombocytopenic Purpura (TTP) - MSD Manuals
Thrombotic thrombocytopenic purpura is suspected in patients with suggestive symptoms, thrombocytopenia, and anemia. If the disorder is suspected, urinalysis and renal function tests, CBC, peripheral blood smear, reticulocyte count, serum LDH, haptoglobin, ADAMTS13 activity and autoantibody (inhibitor) assays, serum bilirubin (direct and ...
Thrombotic Thrombocytopenic Purpura Evaluation and …
2020年10月8日 · Thrombotic thrombocytopenic purpura (TTP) is a rare microangiopathic hemolytic anemia that causes blood clots in small blood vessels. TTP is characterized by fever, hemolytic anemia, thrombocytopenia, and renal and neurologic dysfunction.
Thrombotic Thrombocytopenic Purpura: Pathogenesis, …
Thrombotic thrombocytopenic purpura (TTP), a potentially fatal clinical syndrome, is primarily caused by autoantibodies against the von Willebrand factor (VWF)-cleaving metalloprotease ADAMTS13.
Thrombotic Thrombocytopenic Purpura (TTP) - Heme
On physical exam, her skin is mildly jaundiced. She has multiple purpura over her extremities. Her peripheral smear reveals with schistocytes.
Diagnosing Thrombotic Thrombocytopenic Purpura
People who have TTP have a lower than normal number of platelets in their blood. This test is used with the blood smear to help diagnose TTP. When red blood cells die, they release a protein called hemoglobin (HEE-muh-glow-bin) into the bloodstream. The body breaks down hemoglobin into a compound called bilirubin.