Transforming growth factor beta - Wikipedia
Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes three [1] different mammalian isoforms (TGF-β 1 to 3, HGNC symbols TGFB1, TGFB2, TGFB3) and many other signaling proteins. TGFB proteins are produced by all white blood cell lineages.
TGF-β signaling in health, disease and therapeutics
2024年3月22日 · Transforming growth factor (TGF)-β is a multifunctional cytokine expressed by almost every tissue and cell type. The signal transduction of TGF-β can stimulate diverse cellular...
TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and …
The transforming growth factor-β (TGF-β) is the prototype of the TGF-β family of growth and differentiation factors, which is encoded by 33 genes in mammals and comprises homo- and heterodimers. This review introduces the reader to the TGF-β family with its complexity of names and biological activities.
TGF-β Signaling - PMC
Transforming growth factor-β (TGF-β) represents an evolutionarily conserved family of secreted polypeptide factors that regulate many aspects of physiological embryogenesis and adult tissue homeostasis. The TGF-β family members are also involved in pathophysiological mechanisms that underlie many diseases.
TGF-β signaling in health and disease - Cell Press
2023年9月14日 · TGF-β signaling controls metazoan embryo development, tissue homeostasis, and injury repair through coordinated effects on cell proliferation, phenotypic plasticity, migration, metabolic adaptation, and immune surveillance of multiple cell types in shared ecosystems.
Transforming growth factor-β receptors: versatile mechanisms of …
2024年2月13日 · Transforming growth factor-β (TGF-β) is a ubiquitously expressed cytokine that plays a vital role in regulating a variety of cellular events ranging from organogenesis, differentiation,...
TGF-beta: a master immune regulator - PubMed
Introduction: Transforming Growth Factor-Beta (TGF-β) is a master regulator of numerous cellular functions including cellular immunity. In cancer, TGF-β can function as a tumor promoter via several mechanisms including immunosuppression.
TGFβ signalling in context - Nature Reviews Molecular Cell Biology
2012年9月20日 · Transforming growth factor-β (TGFβ) signalling provides animal cells with a versatile means of driving developmental programmes and controlling cell behaviour, a role that is evident in...
TGF-β Signaling: From Tissue Fibrosis to Tumor Microenvironment
Transforming growth factor-β (TGF-β) signaling triggers diverse biological actions in inflammatory diseases. In tissue fibrosis, it acts as a key pathogenic regulator for promoting immunoregulation via controlling the activation, proliferation, and apoptosis of immunocytes.
TGF-β – an excellent servant but a bad master
2012年9月3日 · Transforming Growth Factor-β (TGF-β) is a key player in cell proliferation, differentiation and apoptosis. The importance of this regulation is apparent from the role of TGF-β in development and consequences of aberrant TGF-β signaling in cancer [3].