TANK-binding kinase 1 - Wikipedia
TBK1 is involved in many signaling pathways and forms a node between them. For this reason, regulation of its involvement in individual signaling pathways is necessary. This is provided by …
Mechanism of TBK1 activation in cancer cells - PMC
TBK1 can be activated either by autophosphorylation of Ser172 or transphosphorylation at this site by upstream kinases. Serving as a hub for integrating numerous extracellular and …
TBK1 recruitment to STING activates both IRF3 and NF-κB that …
2021年4月6日 · We also generated STING mice with mutations that disrupt the recruitment of TANK-binding kinase 1 (TBK1), which is important for both IRF3 and NF-κB activation but not …
TBK1 at the crossroad of signalling pathways - Nature
2018年2月23日 · New research, led by Peng Zhao, now shows that TBK1 suppresses inflammation and energy expenditure in adipose tissue via two separate pathways, indicating …
The role of TBK1 in cancer pathogenesis and anticancer immunity
TBK1 coordinates inflammation and metabolism by regulating downstream signaling pathways. TBK1 regulates the proliferation and survival of malignant cells in many types of cancer. TBK1 …
Targeting TANK-binding kinase 1 (TBK1) in cancer - PMC
2020年11月21日 · TANK-binding kinase 1 (TBK1) is a Ser/Thr kinase with a central role in coordinating the cellular response to invading pathogens and regulating key inflammatory …
Small molecules targeting the innate immune cGAS‒STING‒TBK1 signaling ...
In this perspective, we provide an updated review on the latest progress on the development of small molecule modulators targeting the cGAS‒STING‒TBK1 signaling pathway and their …
TBK1 (TANK-binding kinase 1)-mediated regulation of
2021年6月1日 · In adipose tissue, TBK1 mediates crosstalk between energy sensing and inflammatory signaling pathways [20]. TBK1 directly inhibits AMPK through phosphorylation at …
MARCH1 negatively regulates TBK1-mTOR signaling pathway by ...
2024年7月26日 · We showed that MARCH1 played an important role in growth factor-induced the TBK1- mTOR signaling pathway. MARCH1 overexpression attenuated the growth factor …
IKKε and TBK1 are essential components of the IRF3 signaling pathway
2003年4月14日 · Here we report that the noncanonical IκB kinase homologs, IκB kinase-ε (IKKε) and TANK-binding kinase-1 (TBK1), which were previously implicated in NF-κB activation, are …