T Cell Epitope Prediction and Its Application to Immunotherapy
2021年9月14日 · In this review, we focus on the currently available computational tools for epitope prediction, with a particular focus on tools aimed at identifying neoepitopes, i.e. cancer-specific peptides and their potential for use in immunotherapy for cancer treatment.
Epitope - Wikipedia
An epitope, also known as antigenic determinant, is the part of an antigen that is recognized by the immune system, specifically by antibodies, B cells, or T cells. The part of an antibody that binds to the epitope is called a paratope.
Fundamentals and Methods for T- and B-Cell Epitope Prediction
2017年12月28日 · Here, we analyze aspects of antigen recognition by T- and B-cells that are relevant for epitope prediction. Subsequently, we provide a systematic and inclusive review of the most relevant B- and T-cell epitope prediction methods and tools, paying particular attention to their foundations.
Epitope prediction and identification- adaptive T cell responses in ...
2023年10月31日 · An epitope can be defined as the molecular structure recognized by adaptive immune responses, namely by T cell and B cell receptors and soluble antibodies . In this review, we will focus on T cell epitopes, as this is our principal area of expertise.
T Cell Epitope Predictions - PubMed
2020年4月26日 · MHC ligands that trigger a T cell immune response are referred to as T cell epitopes. Identifying such epitopes enables tracking, phenotyping, and stimulating T cells involved in immune responses in infectious disease, allergy, autoimmunity, transplantation, and cancer.
T-Cell Epitope Prediction - PubMed
The peptides that can be recognized by the T-cell receptors after a particular antigen has been intracellularly processed, bound to at least one MHC molecule and expressed on the surface of the antigen presenting cell as a MHC-peptide complex, are called a T-cell epitope.
T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell ...
2019年8月8日 · Here, we present T-Scan, a high-throughput platform for identification of antigens productively recognized by T cells. T-Scan uses lentiviral delivery of antigen libraries into cells for endogenous processing and presentation on major histocompatibility complex (MHC) molecules.
T-cell epitope vaccine design by immunoinformatics - PMC
The general idea behind the peptide vaccines is based on the chemical approach to synthesize the identified B-cell and T-cell epitopes that are immunodominant and can induce specific immune responses. B-cell epitope of a target molecule can be conjugated with …
T-cell epitope immunogenicity is contingent on three basic steps: (i) antigen processing, (ii) peptide binding to MHC molecules, and (iii) recognition by a cognate TCR.
SARS-CoV-2 human T cell epitopes: Adaptive immune response …
To date, 25 studies have investigated and identified SARS-CoV-2-derived T cell epitopes in humans. Here, we review these recent studies, how they were performed, and their findings.
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