Amino acid - Building Blocks, Structure, Functions | Britannica
2024年10月21日 · Group II amino acids are serine, cysteine, threonine, tyrosine, asparagine, and glutamine. The side chains in this group possess a spectrum of functional groups. However, most have at least one atom (nitrogen, oxygen, or sulfur) with electron pairs available for hydrogen bonding to water and other molecules. The chemical structures of Group II ...
Serine and Cysteine Peptidases: So Similar, Yet Different. How the ...
2022年5月24日 · The catalytic mechanisms of serine and cysteine peptidases are similar: the proton of the nucleophile (serine or cysteine) is transferred to the catalytic histidine, and the nucleophile attacks the substrate for cleavage. However, they differ in an important aspect: cysteine peptidases form a stable ion-pair intermediate in a stepwise mechanism ...
Cysteine metabolic circuitries: druggable targets in cancer
2020年11月23日 · Serine and glycine are needed for cysteine synthesis in one-carbon metabolism, and serine-derived glycine is preferentially used by cancer cells over exogenous glycine. 88 Therefore, in the...
3D interaction homology: Hydropathic interaction environments of serine …
2021年10月1日 · The environments surrounding serine and cysteine residues are dramatically different: serine residues are about 50% solvent exposed, while cysteines are only 10% exposed; the latter are more involved in hydrophobic interactions although there are backbone angle-dependent differences.
Protease mechanisms | Learn Science at Scitable - Nature
Proteases fall into four main mechanistic classes: serine, cysteine, aspartyl and metalloproteases. In the active sites of serine and cysteine proteases, the eponymous residue is usually...
Serine and one-carbon metabolism in cancer - Nature
2016年9月16日 · Because glycine and cysteine are products of serine metabolism, serine depletion leads to reduced levels of glutathione 3, whereas activation of SSP allows glucose-derived carbon to be...
Serine Protease Mechanism and Specificity | Chemical Reviews
2002年11月23日 · Serine and Cysteine Peptidases: So Similar, Yet Different. How the Active-Site Electrostatics Facilitates Different Reaction Mechanisms. The Journal of Physical Chemistry B 2022 , 126 (22) , 4035-4048.
Serine Metabolism in Health and Disease and as a Conditionally ...
System ASC (alanine, serine, and cysteine preferring)— a sodium-dependent transporter, which includes transporters ASCT1 (SLC1A4) and ASCT2 (SLC1A5). It is supposed that ASCT1 is the main transporter for serine in the brain, where it plays a key role in transporting serine from astrocytes and serine uptake by neurons .
3D interaction homology: Hydropathic interaction environments of serine …
2021年10月1日 · Serine and cysteine become less and more, respectively, solvent-exposed in membrane proteins. 3D hydropathic environment maps are an evolving structure analysis tool showing promise as elements in a new protein structure prediction paradigm.
A comprehensive review on signaling attributes of serine and serine ...
2024年1月21日 · Serine is a metabolite with ever-expanding metabolic and non-metabolic signaling attributes. By providing one‑carbon units for macromolecule biosynthesis and functional modifications, serine and serine metabolism largely impinge on cellular survival and function.
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