Mechanism of action of the immunosuppressant rapamycin
Rapamycin has potent immunosuppressive properties reflecting its ability to disrupt cytokine signaling that promotes lymphocyte growth and differentiation. In IL-2-stimulated T cells, …
Sirolimus - Wikipedia
Sirolimus, also known as rapamycin and sold under the brand name Rapamune among others, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection, …
Immunosuppressive potency of mechanistic target of rapamycin …
2016年3月3日 · Inhibition of mTOR by rapamycin suppresses the immune response by preventing cell cycle progression from G1 to S phase, thereby blocking proliferation. In addition, …
Rapamycin: an anti-cancer immunosuppressant? - PubMed
Rapamycin appears to inhibit tumor growth by halting tumor cell proliferation, inducing tumor cell apoptosis, and suppressing tumor angiogenesis. Rapamycin immunosuppressant actions …
Inhibition of the Mechanistic Target of Rapamycin (mTOR)–Rapamycin …
Rapamycin is a Food and Drug Administration (FDA)-approved immunosuppressant and anticancer agent discovered in the soil of Easter Island in the early 1970s. Rapamycin is a …
Rapamycin | Immunosuppressant, Antifungal, Anticancer
Rapamycin exerts its immunosuppressive effects by inhibiting the activation and proliferation of T cells. It acts specifically on FK-binding protein 12 (FKBP12), a substance commonly referred …
Rapamycin golden jubilee and still the miraculous drug: a potent ...
Out of the known immunosuppressants, rapamycin (also known as sirolimus) is ranked among the most potent immunosuppressants. Rapamycin exerts also many bioactivities as shown in Fig. …
Rapamycin: An anti-cancer immunosuppressant? - ScienceDirect
2005年10月1日 · Rapamycin appears to inhibit tumor growth by halting tumor cell proliferation, inducing tumor cell apoptosis, and suppressing tumor angiogenesis. Rapamycin …
Rapamycin: A Bacteria-Derived Immunosuppressant That Has …
2019年1月6日 · Rapamycin (sirolimus), a fermentation product derived from soil samples, has immunosuppressive and anti-proliferation effects. It is an inhibitor of mammalian targets of …
Immune Regulation by Rapamycin: Moving Beyond T Cells
Rapamycin exerts its potent immunosuppressive effects in part through direct effects on antigen-specific lymphocytes; however, rapamycin also modulates adaptive immunity through its …