Proteoglycan - Wikipedia
Proteoglycans are proteins [1] that are heavily glycosylated. The basic proteoglycan unit consists of a "core protein " with one or more covalently attached glycosaminoglycan (GAG) chain (s). [2] The point of attachment is a serine (Ser) residue to which the glycosaminoglycan is joined through a tetrasaccharide bridge (e.g. chondroitin sulfate ...
Proteoglycan - Definition and Examples - Biology Online ...
2022年7月15日 · Proteoglycans are a type of glycoproteins present in the body, especially in connective tissues, bone and cartilage, and cell surfaces. Examples of proteoglycans are versican (a large chondroitin sulfate proteoglycan), perlecan, neurocan, aggrecan, brevican, fibromodulin, and …
Proteoglycans - Physiopedia
Proteoglycan are of a class of glycoproteins of high molecular weight that are found especially in the extracellular matrix of connective tissue (the fibrous tissue that gives support to the body structure).
Chapter 17 Proteoglycans and Sulfated Glycosaminoglycans
This chapter focuses on the structure, biosynthesis, and general biology of proteoglycans. Topics include a description of the major families of proteoglycans, their characteristic polysaccharide chains (glycosaminoglycans), biosynthetic pathways, and …
Proteoglycan form and function: A comprehensive nomenclature ...
We provide a comprehensive classification of the proteoglycan gene families and respective protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular location, overall gene/protein homology, and the utilization of ...
13.3: Proteoglycans - Biology LibreTexts
2022年12月30日 · Proteoglycans are composed of multiple glycosaminoglycans attached to a core protein. These core proteins are sometimes attached to a hyaluronic acid molecule. Negatively charged sugars, like chondroitin sulfate or heparan sulfate, are depicted in yellow.
Proteoglycans in Biomedicine: Resurgence of an Underexploited ...
Proteoglycans have emerged as biomacromolecules with important roles in matrix remodeling, homeostasis, and signaling in the past two decades.