EZH2: biology, disease, and structure-based drug discovery
2013年12月23日 · EZH2 is the catalytic subunit of the polycomb repressive complex 2 (PRC2), which is a highly conserved histone methyltransferase that methylates lysine 27 of histone 3. Overexpression of EZH2...
EZH2 - Wikipedia
Function. EZH2 is the catalytic subunit of the Polycomb Repressive Complex 2 (PRC2). [16] . EZH2's catalytic activity relies on its formation of a complex with at least two other PRC2 components, SUZ12 and EED. [17]
EZH2 Gene - GeneCards | EZH2 Protein | EZH2 Antibody
2024年10月2日 · EZH2 (Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit) is a Protein Coding gene. Diseases associated with EZH2 include Weaver Syndrome and Prc-2 Complex-Related Overgrowth Spectrum. Among its related pathways are RNA Polymerase I Promoter Opening and PIP3 activates AKT signaling.
Regulation of EZH2 protein stability: new mechanisms, roles in ...
2024年2月1日 · Recent technologies focusing on the degradation of EZH2 protein have drawn attention due to their potential robust effects. This review focuses on the molecular mechanisms that regulate EZH2 protein stability via post-translational modifications (PTMs), mainly including ubiquitination, phosphorylation, and acetylation.
Functional characterization of EZH2β reveals the increased …
The EZH2 locus yields two major transcriptional variants: EZH2α and EZH2β. (A) Comparative analysis of the structure of EZH2α and EZH2β transcript variants where sites of alternative splicing events are highlighted in red on the reference isoform.Details of splicing events are described in Table 1.(B) Protein structure differences between EZH2α and EZH2β proteins shows the conservation ...
Structural insights into conformational stability of both wild
2016年10月7日 · Structure of the target protein. The 3D structure of EZH2 containing 229 amino acid residues was determined by X-Ray crystallography at a resolution of 2.0 Å.
Structure of the Catalytic Domain of EZH2 Reveals …
2013年12月19日 · Enhancer of zeste homolog 2 (EZH2) is the catalytic component of polycomb repressive complex 2 (PRC2), an epigenetic regulator of stem cell pluripotency, and expression of tissue-specific genes involved in cellular differentiation and developmental programs [1, 2, …
EZH2, a prominent orchestrator of genetic and ... - ScienceDirect
2022年3月1日 · Enhancer of Zeste Homolog 2 (EZH2) is a histone methyltransferase that catalyzes the histone H3 lysine 27 methylation. It is one of the core subunits of the polycomb-repressive complex2 (PRC2), which consists of several other components such as EED, SUZ12, and RpAp46/48 [1].
Targeting EZH2 for cancer therapy: From current progress to novel ...
2022年8月5日 · Protein targeted degradation technology (such as PROTACs) targeting EZH2 can rapidly reduce the intracellular EZH2 protein level and show strong anti-tumor activity in preclinical studies. Last but not least, PPI inhibitors that block the interactions between EZH2 and other proteins provide a new way for drug discovery and cancer treatment.
EZH2: a novel target for cancer treatment | Journal of Hematology ...
2020年7月28日 · In this review, we summarize the structure and action modes of EZH2, focusing on up-to-date findings regarding the role of EZH2 in cancer initiation, progression, metastasis, metabolism, drug resistance, and immunity regulation. Furtherly, we highlight the advance of targeting EZH2 therapies in experiments and clinical studies.