Plitidepsin | C57H87N7O15 | CID 9812534 - PubChem
Plitidepsin is a cyclic depsipeptide isolated from the marine tunicate Aplidium albicans. Plitidepsin displays a broad spectrum of antitumor activities, inducing apoptosis by triggering mitochondrial cytochrome c release, initiating the Fas/DC95, JNK pathway and activating caspase 3 activation.
Plitidepsin - Wikipedia
Plitidepsin is a cyclic depsipeptide, meaning it is a cyclic peptide in which there is one or more ester bond in place of one or more of a peptide bond. Its chemical structure is very close to that of didemnin B, the only difference being that the lactate residue in didemnin B is present in the oxidized pyruvate version. [citation needed]
Plitidepsin chemical structure. | Download Scientific Diagram
Plitidepsin is a cyclic depsipeptide extracted from the ascidian Aplidium albicans and possess antitumor, antiviral and immunosuppressive activities via its potent inhibitory effect on eukaryotic...
Plitidepsin: design, development, and potential place in therapy
Plitidepsin chemical structure. Plitidepsin was developed in the form of a lyophilized dosage form due to its substantial degradation under heat and light stress testing conditions when solubilized. The optimal reconstitution solution was found to be 15/15/70% (v/v/v) polyoxyl 35 castor oil/ethanol/water for injection.
Chemical structure of plitidepsin (Aplidin®) [14]. - ResearchGate
The chemical structure of plitidepsin closely resembles that of didemnin B isolated from the Caribbean tunicate Trididemmum solidum. ... View in full-text Context 2
Plitidepsin | C57H87N7O15 - ChemSpider
ChemSpider record containing structure, synonyms, properties, vendors and database links for Plitidepsin, 137219-37-5, Aplidine
Plitidepsin - an overview | ScienceDirect Topics
Plitidepsin is a marine-derived anticancer compound separated from the Mediterranean tunicate Applidium albicans. It applies pleiotropic impacts on malignant growth cells, in all likelihood by authoritative to the eukaryotic interpretation eEF1A2.
a Two-dimensional structure and b three-dimensional structure …
At 300 K, plitidepsin and the Mpro of nCoV form a stable complex [107]. Authors have performed the MD simulations repurposed drugs acyclovir (A), ganciclovir (G), and a ganciclovir derivative (D...
Plitidepsin: design, development, and potential place in therapy
2017年1月19日 · Plitidepsin is a cyclic depsipeptide that was first isolated from a Mediterranean marine tunicate Citation 1 (Aplidium albicans) and, at present, is manufactured by total synthesis and commercialized as plitidepsin. Its antitumor activity, observed in preclinical in vitro and in vivo studies, has prompted numerous clinical trials during the ...
Definition of plitidepsin - NCI Drug Dictionary - NCI
A cyclic depsipeptide isolated from the marine tunicate Aplidium albicans. Plitidepsin displays a broad spectrum of antitumor activities, inducing apoptosis by triggering mitochondrial cytochrome c release, initiating the Fas/DC95, JNK pathway and activating caspase 3 activation.
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