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A phosphoinositide signalling pathway mediates rapid lysosomal …
2022年9月7日 · Here, using an unbiased proteomic approach, we show that LMP stimulates a phosphoinositide-initiated membrane tethering and lipid transport (PITT) pathway for rapid lysosomal repair.
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The PITT pathway: Keeping lysosomes young - Wiley Online Library
The phosphoinositide-initiated membrane tethering and lipid transport (PITT) pathway is essential for rapid lysosomal repair. It is activated by multiple distinct, disease-related lysosome-damaging conditions, suggesting that it is a common mechanism for lysosomal quality control.
The PITT pathway: Keeping lysosomes young - PMC - National …
2022年10月25日 · The phosphoinositide‐initiated membrane tethering and lipid transport (PITT) pathway is essential for rapid lysosomal repair. It is activated by multiple distinct, disease‐related lysosome‐damaging conditions, suggesting that it is a common mechanism for …
Phosphoinositide signal for lysosomal membrane repair
2022年10月7日 · Tan and Finkel now uncover a novel phosphoinositide-initiated membrane tethering and lipid transport (PITT) pathway required to rapidly resolve LMP associated with lysosome damage.
PITT 途径：保持溶酶体年轻,Clinical and Translational Medicine - X …
pitt 通路由 pi4p 信号触发，驱动广泛的 er-溶酶体膜接触，支持多种脂质转移过程，从而实现直接和快速的溶酶体修复。 PITT 途径第一种酶 PI4K2A 的溶酶体募集是由多种外源性物质或疾病相关条件激活的，这些因素通过不同的机制损害溶酶体膜 10 （图 1）。
Lysosomal quality control: molecular mechanisms and therapeutic ...
2023年9月1日 · The PITT pathway rapidly repairs lysosomes by directly transferring lipids to damaged membranes. Multiple pathophysiologically relevant lysosomal-damaging conditions trigger the rapid recruitment of phosphatidylinositol-4 kinase type 2α (PI4K2A) to lysosomes, leading to robust generation of phosphatidylinositol 4-phosphate (PI4P), a lipid ...
The PITT pathway: Keeping lysosomes young - PubMed
The PITT pathway: Keeping lysosomes young. Clin Transl Med. 2022 Oct;12 (10):e1097. doi: 10.1002/ctm2.1097. Authors. Haoxiang Yang 1 , Jay Xiaojun Tan 1 2. Affiliations. 1 Aging Institute, University of Pittsburgh School of Medicine/University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
The PITT pathway is triggered by PI4P signalling thatdrivesextensiveER-lysosomemembranecontactsto supportmultiplelipidtransferprocessesfordirectand rapidlysosomalrepair.Thelysosomalrecruitmentofthe
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