PCNA Gene - GeneCards | PCNA Protein | PCNA Antibody
2024年10月2日 · PCNA (Proliferating Cell Nuclear Antigen) is a Protein Coding gene. Diseases associated with PCNA include Ataxia-Telangiectasia-Like Disorder 2 and Actinic Keratosis. Among its related pathways are Base excision repair and Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template.
Proliferating cell nuclear antigen - Wikipedia
Proliferating cell nuclear antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for replication. PCNA is a homotrimer and achieves its processivity by encircling the DNA, where it acts as a scaffold to recruit proteins involved in DNA replication, DNA repair, chromatin ...
增殖细胞核抗原 - 百度百科
增殖细胞 核抗原（Proliferating Cell Nuclear Antigen简称PCNA）由Miyachi等于1978年在 SLE（系统性红斑狼疮）患者的血清中首次发现并命名，因其只存在于正常增殖细胞及 肿瘤细胞 内而得名，以后的研究发现PCNA与细胞 DNA合成 关系密切，在 细胞增殖 的启动上起重要作用 ...
Proliferating cell nuclear antigen (PCNA): a key factor in DNA ...
Background: PCNA (proliferating cell nuclear antigen) has been found in the nuclei of yeast, plant and animal cells that undergo cell division, suggesting a function in cell cycle regulation and/or DNA replication. It subsequently became clear that PCNA also played a role in other processes involving the cell genome.
The role of PCNA as a scaffold protein in cellular signaling is ...
Proliferating cell nuclear antigen (PCNA), a member of the highly conserved DNA sliding clamp family, is an essential protein for cellular processes including DNA replication and repair. A large number of proteins from higher eukaryotes contain one ...
5111 - Gene ResultPCNA proliferating cell nuclear antigen
PCNA physically interacts with and directly binds AP endonuclease 1 (APE1) in whole cell extracts, thus demonstrating involvement of multiprotein reactions during long-patch base excision repair. The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta.
PCNA proliferating cell nuclear antigen [Homo sapiens (human)] - Gene ...
2024年9月19日 · The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication.
PCNA: structure, functions and interactions - PubMed
1997年2月13日 · Proliferating cell nuclear antigen (PCNA) plays an essential role in nucleic acid metabolism as a component of the replication and repair machinery. This toroidal-shaped protein encircles DNA and can slide bidirectionally along the duplex. One of the well-established functions for PCNA is its role a ….
Targeting Proliferating Cell Nuclear Antigen (PCNA) as an …
Proliferating Cell Nuclear Antigen (PCNA) is an essential protein that participates in a variety of processes of DNA metabolism, including DNA replication and repair, chromatin organization and transcription and sister chromatid cohesion. In addition, PCNA is involved in cell survival, and possibly in pathways of energy metabolism, such as ...
PCNA: structure, functions and interactions | Oncogene
1997年2月13日 · Proliferating cell nuclear antigen (PCNA) plays an essential role in nucleic acid metabolism as a component of the replication and repair machinery. This...