The Cross Talk Between p53 and mTOR Pathways in Response to …
2021年11月18日 · In this review, we first briefly introduce the tumor suppressor p53 and then describe the upstream regulators and downstream effectors of the mTOR pathway. Next, we discuss the role of p53 in regulating the mTOR pathway through its transcriptional and non-transcriptional effects.
The Cross Talk Between p53 and mTOR Pathways in Response to ...
2021年11月18日 · Accumulating evidence indicates that the tumor suppressor p53 regulates the machinery of the mTOR pathway at multiple levels to control a broad array of cellular processes, including cell proliferation, apoptosis, autophagy, migration, and tumorigenesis.
新成果｜Genes Dev：顾伟团队在p53-mTOR及铁死亡领域新突破
2020年12月24日 · 这些结果说明了p53除了通过诱导细胞凋亡，周期阻滞，衰老和铁死亡外，还可以通过mTOR pathway来抑制肿瘤的发展和胚胎发育。. 为了研究p53在缺失凋亡，细胞周期阻滞，衰老和铁死亡功能后能否导致肿瘤的发展，作者构建了p53 4KR的小鼠，通过实验发 …
Targeting p53 pathways: mechanisms, structures and advances in …
2023年3月1日 · p53 inhibits mTOR and enhances autophagy by activating AMP-responsive protein kinase. 177,178,179 The p53 target genes Sestrin1 and Sestrin2 phosphorylate and activate AMPK and promote...
p53-mediated AKT and mTOR inhibition requires RFX7 and DDIT4 …
2021年12月14日 · We provide evidence that DDIT4 is required for p53 to inhibit mTOR complex 2 (mTORC2)-dependent AKT activation. Most strikingly, we also find that the DDIT4 regulator RFX7 is required for p53...
The coordinate regulation of the p53 and mTOR pathways in cells
2005年6月7日 · The results presented here demonstrate that activation of p53 inhibits mTOR activity and regulates its downstream targets, including autophagy, a tumor suppression process. Moreover, the mechanisms by which p53 regulates mTOR involves AMP kinase activation and requires the tuberous sclerosis (TSC) 1/TSC2 complex, both of which respond to energy ...
mTORC1 and p53: Clash of the gods? - PMC
Open in a new tab. Figure 1. The integration of DNA damages response with cell growth. (1) The ATM response (red box) activates p53 to inhibit mTORC1 through AMPK/TSC1/2. (2) The p38α/AKT/mTORC1/S6K1 response (green box) inhibits MDM2 suppression of p53 which inhibits mTORC1. (3) The combination of p53/p21 cell cycle arrest and mTORC1-induced ...
Tumor suppressor p53 restrains cancer cell dissemination by
2022年5月19日 · Here, we unravel how p53 modulates mitochondrial dynamics to restrain the metastatic properties of cancer cells. p53 inhibits the mammalian target of rapamycin complex 1 (mTORC1) signaling to...
mTOR inhibition and p53 activation, microRNAs: The possible …
2020年6月30日 · The established drug target molecules, such as, Rapamycin and Everolimus function as mTOR inhibitors or p53 activators such as nutlin 3a can stabilize p53 by degrading Mdm2 could help to inhibit virus replication. Also, p53 activators were found to inhibit mTOR signaling via the AMPK pathway in mantle cell lymphoma.
PI3K/Akt-mediated regulation of p53 in cancer - PubMed
Mutations activating the PI3K (phosphoinositide 3-kinase)/Akt signalling pathway and inactivating the TP53 tumour-suppressor gene are common mechanisms that cancer cells require to proliferate and escape pre-programmed cell death. In a well-described mechanism, Akt mediates negative control of p53 l ….
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