Osteoblast Differentiation at a Glance - PMC
Osteoblasts are bone-building cells of mesenchymal origin; they differentiate from mesenchymal progenitors, either directly or via an osteochondroprogenitor. The direct pathway is typical for intramembranous ossification of the skull and clavicles, while the latter is a hallmark of endochondral ossification of the axial skeleton and limbs.
Osteoblast Differentiation and Signaling: Established Concepts …
In this review, we focus on one of the two key players in bone modeling/remodeling: the osteoblast, discussing the latest developments in the signaling and transcriptional regulation in osteoblast differentiation in physio-/pathological conditions.
Osteoblast Differentiation and Signaling: Established Concepts …
2021年6月22日 · In this review, we discuss well-established pathways of osteoblastic differentiation, i.e., the classical ones committing mesenchymal stromal cells to osteoblast, and then osteocytes as well as recently emerged players.
In vitro osteoblastic differentiation of mesenchymal stem cells ...
2018年7月27日 · Differentiation of mesenchymal stem cells to osteoblasts is widely performed in research laboratories. Classical tests to prove this differentiation employ procedures such as cell fixation, cell lysis or cell scraping.
Osteoblast Differentiation at a Glance - PubMed
2016年9月26日 · Osteoblasts are bone-building cells of mesenchymal origin; they differentiate from mesenchymal progenitors, either directly or via an osteochondroprogenitor. The direct pathway is typical for intramembranous ossification of the skull and clavicles, while the latter is a hallmark of endochondral ossification of the axial skeleton and limbs.
Osteoblast Differentiation and Bone Matrix Formation
Three classes of (usually) cell surface- or matrix-bound GDFs have profound effects on osteoblast differentiation, the transforming growth factor β (TGFβ) superfamily (including BMPs and GDFs), the FGF family, and the TNF family.
Cell signaling and transcriptional regulation of osteoblast lineage ...
2024年7月2日 · PTH regulates osteoblast differentiation by binding with PTH1R, subsequently activating cAMP and PKA, leading to the phosphorylation of CREB to regulate osteoblast-specific gene expression.
Bioenergetic metabolism in osteoblast differentiation - PMC
Osteoblast differentiation and bone formation are energetically demanding processes due in part to high rates of macromolecule (e.g., protein, DNA and RNA) biosynthesis associated with proliferation and matrix production.
Osteoblastic cells: Differentiation and trans ... - ScienceDirect
2008年5月15日 · The osteoblast is the bone forming cell and is derived from mesenchymal stem cells (MSC) present among the bone marrow stroma. MSC are capable of multi-lineage differentiation into mesoderm-type cells such as osteoblasts and adipocytes.
Osteoblast Differentiation - an overview | ScienceDirect Topics
Mature osteoblasts secrete bone ECM proteins, such as type I collagen. Typical gene indicators of osteoblast differentiation are Runx2, distal-less homeobox 5 (Dlx5), Osterix, alias core-binding factor alpha1 (Cbfa1), osteoblast specific factor 2 (Osf2) and ColIA1 [125, 126].
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