Nrf2 suppresses macrophage inflammatory response by blocking ...
2016年5月23日 · Here, we demonstrate that Nrf2 interferes with lipopolysaccharide-induced transcriptional upregulation of proinflammatory cytokines, including IL-6 and IL-1β. Chromatin immunoprecipitation...
Nrf2 suppresses macrophage inflammatory response by …
2016年5月23日 · Here, we demonstrate that Nrf2 interferes with lipopolysaccharide-induced transcriptional upregulation of proinflammatory cytokines, including IL-6 and IL-1β. Chromatin immunoprecipitation (ChIP)-seq and ChIP-qPCR analyses revealed that Nrf2 binds to the proximity of these genes in macrophages and inhibits RNA Pol II recruitment.
Macrophage achieves self-protection against oxidative stress …
2019年2月14日 · We further show that Mst1/2 function as critical ROS sensors and attenuators through stabilizing nuclear factor (erythroid-derived 2)-like 2 (Nrf2, also known as NFE2L2), a major antioxidant...
Nrf2 activation reprograms macrophage intermediary …
2022年2月18日 · To understand how Nrf2 regulates macrophage biology, we used high-resolution mass spectrometry (MS) to characterize the proteomes of bone marrow-derived macrophages (BMDMs) differentiated ex vivo from bone marrow cells isolated from, respectively, wild-type (WT), Keap1-knockdown (Keap1-KD, expressing ∼70% lower levels of Keap1 compared to WT ...
Itaconate is an anti-inflammatory metabolite that activates Nrf2 …
2018年3月28日 · Our findings demonstrate that itaconate is a crucial anti-inflammatory metabolite that acts via Nrf2 to limit inflammation and modulate type I interferons. Macrophages have a key role in innate...
Nrf2 Signaling in Macrophages - PMC - National Center for …
Macrophages act as major players in inflammatory responses. Because oxidative stress and inflammation are two intertwined processes, the anti-inflammatory activity of Nrf2 signaling is believed to result from its upregulation of cellular antioxidant defenses via the antioxidant response element-driven transcription.
Nrf2-mediated anti-inflammatory polarization of macrophages as ...
2022年8月12日 · In this review, we reviewed the role of macrophage phenotypes in driving and relieving inflammation due to OA and summarized how NF-κB, Nrf2, and their crosstalk shape macrophage polarization. As Nrf2 signaling is believed to impact cellular metabolism, studying the effects of activators of Nrf2 on macrophage metabolism and phenotype related ...
Nrf2 suppresses macrophage inflammatory response by blocking ...
Here, we demonstrate that Nrf2 interferes with lipopolysaccharide-induced transcriptional upregulation of proinflammatory cytokines, including IL-6 and IL-1β. Chromatin immunoprecipitation (ChIP)-seq and ChIP-qPCR analyses revealed that Nrf2 binds to the proximity of these genes in macrophages and inhibits RNA Pol II recruitment.
Macrophage Nrf 2 the rescue - PMC
Using several approaches, including RNAi-mediated Nrf2 depletion in fly lines, macrophage Nrf2 was implicated in cytoprotection, acting as a buffer to phagosomal ROS and importantly, reducing damage to the embryonic macrophages themselves . Macrophage Nox is also shown to mediate ROS production downstream of cell corpse phagocytosis, initiating ...
Role of the transcription factor NRF2 in maintaining the integrity …
2 天之前 · NRF2 pathway is activated in response to CS in resident macrophages, bronchial and alveolar epithelium, and lung fibroblasts of chronic smokers . Following TS exposure, NRF2 translocates to the nucleus and promotes the expression of detoxification enzymes and antioxidants (Fig. 6 ) [ 88 ], which reduce inflammation and restore TJ protein ...