Non-histone protein - Wikipedia
The non-histone proteins, are a large group of heterogeneous proteins that play a role in organization and compaction of the chromosome into higher order structures. They play vital roles in regulating processes like nucleosome remodeling, DNA replication, RNA synthesis and processing, nuclear transport, steroid hormone action and interphase ...
Functions and mechanisms of non-histone protein acetylation
2018年11月22日 · Non-histone-lysine acetylation affects protein functions by modulating protein stability, interactions, subcellular localization and enzymatic activity and through crosstalk...
Acetylation of histones and non-histone proteins is not a mere
2024年6月11日 · The work presents proteome-scale quantification of lysine acetylation after acute transcription inhibition, revealing that histone and non-histone protein acetylation remains largely unchanged...
长文解析Nature综述：全面了解！ 非组蛋白乙酰化修饰的功能与机制
2019年1月7日 · 哺乳动物组蛋白乙酰基转移酶（HAT）、去乙酰化酶（HDAC）的发现与鉴定，乙酰赖氨酸Reader结构域的发现，以及去乙酰化酶抑制剂的发现为非组蛋白乙酰化修饰的研究铺平了道路。 在过去的十年中，基于质谱的蛋白质组学极大地加速了内源性乙酰化蛋白质的发现与鉴定，同时也揭示了非组蛋白乙酰化的调节过程。 鉴于非组蛋白乙酰化的发现，HAT和HDAC分别更名为赖氨酸乙酰转移酶（KAT）和赖氨酸脱乙酰酶（KDAC）。 成千上万个乙酰化位点的鉴定引 …
Functions and mechanisms of non-histone protein acetylation
In the past decade, proteomic analyses have revealed that non-histone proteins are frequently acetylated and constitute a major portion of the acetylome in mammalian cells. Indeed, non-histone protein acetylation is involved in key cellular processes relevant to physiology and disease, such as gene transcription, DNA damage repair, cell ...
Non-histone protein methylation as a regulator of cellular …
2014年12月10日 · Methylation of Lys and Arg residues on non-histone proteins has emerged as a prevalent post-translational modification and as an important regulator of cellular signal transduction mediated by...
Functions and mechanisms of non‐histone protein acetylation in …
2024年8月13日 · We focus primarily on the large-scale identification of acetylated proteins and sites in various plant species, the biological roles of non-histone acetylation modifications, the enzymes and associated protein complexes involved in acetylation modifications, and the functional mechanisms of non-histone acetylation, which collectively serve to ...
Non-Histone Protein Methylation: Biological Significance and ...
2021年2月19日 · Here, we report the latest findings, highlighting how non-histone protein methylation is fundamental for certain cellular functions and is implicated in disease, and review recent efforts in the engineering of protein methylation.
Acetylation and deacetylation of non-histone proteins
2005年12月19日 · Deacetylation of these non-histone proteins by histone deacetylases (HDACs) opens yet another exciting new field of discovery in the role of the dynamic acetylation and deacetylation on cellular function. This review will focus on these non-histone targets of HATs and HDACs and the consequences of their modification.
Modulation of cellular processes by histone and non-histone …
2022年1月18日 · In this Review, we synthesize the most recent discoveries in the field of histone and non-histone acetylation. We begin by describing the influence of histone acetylation on transcription,...