5-Methylcytosine - Wikipedia
5-Methylcytosine is a methylated form of the DNA base cytosine (C) that regulates gene transcription and takes several other biological roles. [1]
5-methylcytosine turnover: Mechanisms and therapeutic …
DNA methylation at the fifth position of cytosine (5mC) is one of the most studied epigenetic mechanisms essential for the control of gene expression and for many other biological processes including genomic imprinting, X chromosome inactivation and genome stability.
The Curious Chemical Biology of Cytosine: Deamination, Methylation …
Numerous mechanisms have been proposed for DNA demethylation, in which 5-methylcytosine (bold, top right) is converted to cytosine (bold, bottom right). Current evidence supports the existence of an iterative oxidation, BER-coupled pathway (orange) in embryonic stem cells.
Epigenetic regulatory functions of DNA modifications: 5-methylcytosine …
5-Methylcytosine has been termed the “fifth base” of the human genome. This reflects the relatively high abundance of this modification, as about 4% of the cytosine residues in the human genome have been found to be methylated. However, cytosine methylation levels can differ greatly among animal genomes (see below), and it would therefore ...
5-Methylcytosine - an overview | ScienceDirect Topics
5-Methylcytosine (5mC) is an enzymatically produced modified cytosine base that has been known to exist in mammalian DNA for about 70 years. These decades of research have provided important clues as to its presumed functional role but there is no complete understanding yet.
5-Methylcytosine - an overview | ScienceDirect Topics
5-Methylcytosine is the most abundant DNA base modification present in the eukaryotic cells that is associated with gene repression. The distribution and aberrations in 5-methylcytosine have been studied extensively during normal development and in …
5-Methylcytosine | C5H7N3O | CID 65040 - PubChem
5-methylcytosine is a pyrimidine that is a derivative of cytosine, having a methyl group at the 5-position. It has a role as a human metabolite. It is a member of pyrimidines and a methylcytosine. It is functionally related to a cytosine.
New themes in the biological functions of 5-methylcytosine and …
DNA methylation is catalyzed through an enzymatic reaction that requires the DNA methyltransferases (DNMTs) and S-adenosyl methionine (SAM) as the methyl group donor. In somatic tissues, DNA methylation occurs almost exclusively at the C5 position of a cytosine in a 5′-CpG-3′ dinucleotide.
Accurate estimation of 5-methylcytosine in mammalian ... - Nature
2018年4月11日 · Methylation of the fifth carbon of cytosine residues in mammalian nuclear DNA plays crucial epigenetic regulatory roles in diverse processes, including differentiation and cellular...
Frontiers | 5-methylcytosine turnover: Mechanisms and …
2022年8月16日 · DNA methylation at the fifth position of cytosine (5mC) is one of the most studied epigenetic mechanisms essential for the control of gene expression and for many other biological processes including genomic imprinting, X …
DNA methylation and its basic function - PubMed
In the mammalian genome, DNA methylation is an epigenetic mechanism involving the transfer of a methyl group onto the C5 position of the cytosine to form 5-methylcytosine. DNA methylation regulates gene expression by recruiting proteins involved in gene repression or by inhibiting the binding of tra ….
Ultrafast bisulfite sequencing detection of 5-methylcytosine in …
2024年1月2日 · 5-Methylcytosine (5mC) in DNA is a fundamental epigenetic mark having crucial roles in regulating gene expression, chromatin organization and cellular identity 1.
Direct enzymatic sequencing of 5-methylcytosine at single-base …
2023年6月15日 · 5-methylcytosine (5mC) is the most important DNA modification in mammalian genomes. The ideal method for 5mC localization would be both nondestructive of DNA and direct, without requiring...
DNA methylation - Wikipedia
Representation of a DNA molecule that is methylated. The two white spheres represent methyl groups. They are bound to two cytosine nucleotide molecules that make up the DNA sequence. DNA methylation is a biological process by which methyl groups are added to the DNA molecule.
New themes in the biological functions of 5-methylcytosine …
5-methylcytosine (5-mC) and 5-hydroxymethylcytosine (5-hmC) play a critical role in development and normal physiology. Alterations in 5-mC and 5-hmC patterns are common events in hematopoietic neoplasms.
RNA 5-methylcytosine modification and its emerging role as an ...
5-methylcytosine (m5C) is identified as an abundant and conserved modification in various RNAs, including tRNAs, mRNAs, rRNAs, and other non-coding RNAs. The application of high-throughput sequencing and mass spectrometry allowed for the detection ...
Genome-wide identification of mRNA 5-methylcytosine in …
2019年5月6日 · Accurate and systematic transcriptome-wide detection of 5-methylcytosine (m 5 C) has proved challenging, and there are conflicting views about the prevalence of this modification in mRNAs.
5-methylcytosine (m5C) RNA modification controls the innate ... - PNAS
5-methylcytosine (m 5 C) is one of the most prevalent modifications of RNA, playing important roles in RNA metabolism, nuclear export, and translation. However, the potential role of RNA m 5 C methylation in innate immunity remains elusive.
5-Hydroxymethylcytosine: Far Beyond the Intermediate of DNA
2024年11月2日 · Epigenetics plays a pivotal role in regulating gene expression and cellular differentiation. DNA methylation, involving the addition of methyl groups to specific cytosine bases, is a well-known epigenetic modification. The recent discovery of 5-hydroxymethylcytosine (5hmC) has provided new insights into cytosine modifications. 5hmC, derived from the …
DNA 5-methylcytosine detection and methylation phasing using …
2023年7月8日 · 5-methylcytosine (5mC), the most common form of DNA methylation, is involved in regulating many biological processes 1. In humans, most 5mCs occur at CpG sites, which are associated with...
Bacterial N4-methylcytosine as an epigenetic mark in ... - Nature
2022年2月28日 · In eukaryotes, modifications predominantly involve C5-methylcytosine (5mC) and occasionally N6-methyladenine (6mA), while bacteria frequently use N4-methylcytosine (4mC) in addition to 5mC...