Mast cell - Wikipedia
A mast cell (also known as a mastocyte or a labrocyte[1]) is a resident cell of connective tissue that contains many granules rich in histamine and heparin. Specifically, it is a type of granulocyte derived from the myeloid stem cell that is a part of the immune and neuroimmune systems.
Mast cell secretory granules: armed for battle - Nature
2014年6月6日 · Mast cell secretory granules are lysosome-like organelles that contain a large panel of preformed bioactive constituents, including lysosomal hydrolases, amines, cytokines,...
Mast cell secretory granules: armed for battle - PubMed
Mast cells are distinguished by their high content of electron-dense secretory granules, which are filled with large amounts of preformed and pre-activated immunomodulatory compounds. When appropriately activated, mast cells undergo degranulation, a process by which these preformed granule compounds are rapidly released into the surroundings.
Mast Cell Mediators: Their Differential Release and the Secretory ...
Mast cells granules, also called secretory lysosomes, contain both lysosomal proteins such as acid hydrolases, e.g., β-hexosaminidase, as well as mediators such as histamine, and can secrete both together. MC also contain traditional lysosomes that can release enzymes such as β-hexosaminidase independently of histamine .
Mast Cell: A Multi-Functional Master Cell - PMC - PubMed …
Mast cells are located in areas below the epithelium in connective tissue surrounding blood cells, smooth muscle, mucous, and hair follicles. The cytoplasm of the mast cell contains 50–200 large granules that store inflammatory mediators, including histamine, heparin, a variety of cytokines, chondroitin sulfate, and neutral proteases .
Characterization of Mast Cell Secretory Granules and Their Cell …
2014年10月1日 · Exocytosis and secretion of secretory granule (SG) contained inflammatory mediators is the primary mechanism by which mast cells exert their protective immune responses in host defense, as well as their pathological functions in allergic reactions and anaphylaxis.
SLC10A4 regulates IgE-mediated mast cell degranulation in
2017年4月24日 · Mast cell granules contain mast cell-specific proteases: tryptase, chymase and carboxypeptidase A, which are presumably sorted into the mast cell progranules directly from the trans-golgi...
Tailor-made mast-cell granules | Nature Materials
2012年2月21日 · Mast cells induce protective immune responses through secretion of stimulatory granules. Microparticles modelled after mast-cell granules are now shown to replicate and enhance the...
Mast cell secretory granule fusion with amphisomes coordinates …
Mast cell secretory granules (SGs) enlarge via Rab5-regulated fusion. Omari et al. found that SGs enlarge by fusion of individual SGs with amphisomes and decrease in size through dynamin-mediated fission regulated by phosphoinositide interconversions. While both small and large SGs are exocytosis competent, only large SGs can release exosomes.
Mast cell granules: Modulating adaptive immune response …
Owing to their localization at barrier interfaces and the readily available ammunition of preformed granules, mast cells are perfectly poised to regulate immune responses during infections.
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