Double Muscling in Cattle: Genes, Husbandry, Carcasses and Meat
Molecular biology has enabled the identification of the mechanisms whereby inactive myostatin increases skeletal muscle growth in double-muscled (DM) animals. Myostatin is a secreted growth differentiation factor belonging to the transforming growth factor-β superfamily. Mutations make the myostatin gene inactive, resulting in muscle hypertrophy.
The myostatin gene: an overview of mechanisms of action and its ...
2018年8月20日 · Here, we firstly give an overview of the molecular pathways regulated by myostatin that control muscle development. Then we describe the natural mutations and their associated phenotypes as well as the physiological influence of altering myostatin expression in livestock animals (cattle, sheep, goat, horse, pig, rabbit and chicken).
Double Muscling in Cattle: Genes, Husbandry, Carcasses and Meat
2012年9月20日 · Myostatin is a secreted growth differentiation factor belonging to the transforming growth factor-β superfamily. Mutations make the myostatin gene inactive, resulting in muscle hypertrophy. The relationship between the different characteristics of DM cattle are defined with possible consequences for livestock husbandry.
Double Muscling in Cattle: Genes, Husbandry, Carcasses and Meat
Molecular biology has enabled the identification of the mechanisms whereby inactive myostatin increases skeletal muscle growth in double-muscled (DM) animals. Myostatin is a secreted growth differentiation factor belonging to the transforming growth factor-β superfamily. Mutations make the myostatin gene inactive, resulting in muscle hypertrophy.
Frontiers | Deciphering Myostatin’s Regulatory, Metabolic, and ...
Myostatin null mice (mstn −/−) exhibit skeletal muscle fiber hyperplasia and hypertrophy whereas myostatin deficiency in larger mammals like sheep and pigs engender muscle fiber hyperplasia. Myostatin’s impact extends beyond muscles, with alterations in myostatin present in the pathophysiology of myocardial infarctions, inflammation ...
Myostatin inactivation induces a similar muscle molecular …
2011年1月1日 · Myostatin (MSTN), a member of the TGF-β superfamily, is a negative regulator of skeletal muscle mass. We have previously shown that the cell survival/apoptosis pathway is a downstream target of MSTN loss-of-function in mice through the regulation of the expression or abundance of many survival and apoptotic factors.
Proteomic Studies on the Mechanism of Myostatin Regulating …
2021年11月16日 · MSTN deficiency resulting from genetic ablation of both copies (MSTN −/-) or single copy (MSTN +/−) of the germline allele or loss-of-function mutations usually leads to a “double muscle” phenotype, mainly characterized by a significant increase in muscle mass (McPherron, 1997; McPherron et al., 1997).
Mapping genetic loci that interact with myostatin to affect growth ...
2011年6月22日 · Myostatin, or GDF8, is an inhibitor of skeletal muscle growth. A non-functional myostatin mutation leads to a double muscling phenotype in some species, for example, mice, cattle and humans....
Growth Traits and Sperm Proteomics Analyses of Myostatin Gene …
2022年4月23日 · To date, at least six functional mutations have been found in the myostatin (MSTN) gene of different breeds of cattle, including Belgian Blue, Piedmontese, Charolais, Blonde d’Aquitaine, Limousin, and German Gelbvieh.
Comparative functional analysis of the cow and mouse myostatin …
2008年8月1日 · In the present study, equivalent lengths of the upstream promoter sequence of the mouse, human and cow myostatin genes showed the most differential activity in C 2 C 12 myotubes in vitro, with the mouse myostatin promoter showing approximately 2–3-fold greater activity in these cells than either the human or cow promoters, which were not ...
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