Linear epitope - Wikipedia
In immunology, a linear epitope (also sequential epitope) is an epitope—a binding site on an antigen—that is recognized by antibodies by its linear sequence of amino acids (i.e. primary structure).
Epitope - Wikipedia
An epitope, also known as antigenic determinant, is the part of an antigen that is recognized by the immune system, specifically by antibodies, B cells, or T cells.The part of an antibody that binds to the epitope is called a paratope.Although epitopes are usually non-self proteins, sequences derived from the host that can be recognized (as in the case of autoimmune diseases) are also epitopes.
Linear Epitope - an overview | ScienceDirect Topics
Linear epitopes are usually composed of sequential amino acids that participate in antibody binding and their interaction is based on the primary structure of the epitope. CD8 T-cell epitopes presented by MHC I molecules are typically linear peptides with length that ranges from 8 …
Linear epitopes of SARS-CoV-2 spike protein elicit neutralizing ...
2020年9月7日 · Linear epitope mapping of SARS-CoV-2 S protein and neutralizing activities of the elicited antibodies. a Heatmap of IgG antibody responses of 55 sera from COVID-19 convalescent patients and...
Prediction of linear B-cell epitopes based on protein sequence …
2024年1月30日 · Linear B-cell epitopes (BCEs) play a key role in the development of peptide vaccines and immunodiagnostic reagents. Therefore, the accurate identification of linear BCEs is of great...
High-resolution Mapping of Linear Antibody Epitopes Using …
2012年9月13日 · These results show that ultrahigh-density peptide microarrays can be used for linear epitope mapping. With an upper theoretical limit of 2,000,000 individual peptides per array, these peptide microarrays may even be used for a systematic validation of …
An overview of methods for the structural and functional mapping of ...
Linear epitopes are those that involve sequential residues in the primary amino acid sequence and can be identified using techniques like peptide microarrays, phage, or bacterial display. By contrast, conformational epitopes involve surfaces recognized by antibodies only when a protein is folded in its tertiary or quaternary state.
EpitopeVec: linear epitope prediction using deep protein …
2021年6月28日 · We describe a new method called EpitopeVec, which uses a combination of residue properties, modified antigenicity scales, and protein language model-based representations (protein vectors) as features of peptides for linear BCE predictions.
The immunodominant and neutralization linear epitopes for SARS …
Here, we simulate the 3D structures and predict the B cell epitopes on the spike (S), envelope (E), membrane (M), and nucleocapsid (N) proteins of SARS-CoV-2 using structure-based approaches and validate epitope immunogenicity by immunizing mice.
epitope1D: accurate taxonomy-aware B-cell linear epitope …
2023年4月10日 · epitope1D is a novel and accurate linear B-cell epitope predictor based on an explainable machine learning. We have curated the largest, non-redundant experimentally derived epitope data set to date, covering a large number of organisms.
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