Isoxazole 9 (ISX9), a small molecule targeting Axin, activates …
Background and purpose: Isoxazole 9 (ISX9) is a neurogenesis-promoting small molecule compound that can up-regulate the expression of NeuroD1 and induce differentiation of …
The synthetic and therapeutic expedition of isoxazole and its …
Kalirajan et al. synthesized isoxazole substituted 9-anilinoacridine derivatives and evaluated them for in vitro antioxidant, as well as cytotoxic activity against Hep2 cell line
ISX-9 (Isoxazole 9) | 神经干细胞分化诱导剂 | MCE
ISX-9 (Isoxazole 9) is a potent inducer of adult neural stem cell differentiation. ISX-9 activates Ca 2+ influx through both voltage-gated Ca 2+ channels and NMDA receptors and increases …
Isoxazole 9 (ISX9), a small molecule targeting Axin, activates …
2023年1月31日 · Isoxazole 9 (ISX9) is a neurogenesis-promoting small molecule compound that can up-regulate the expression of NeuroD1 and induce differentiation of neuronal, cardiac and …
Isoxazole - Wikipedia
Isoxazole is an electron-rich azole with an oxygen atom next to the nitrogen. It is also the class of compounds containing this ring. Isoxazolyl is the univalent functional group derived from …
Differential Effects of Isoxazole-9 on Neural Stem/Progenitor Cells ...
2015年9月25日 · Isoxazole 9 (Isx-9) is a synthetic small molecule that promotes adult neurogenesis [6,7]. It has been shown that Isx-9 can trigger neuronal differentiation of adult …
A synthetic small-molecule Isoxazole-9 protects against ... - Nature
2017年3月28日 · Systemic treatment with the drug Isoxazole-9 (a synthetic small molecule known to modulate neurogenesis in the adult rodent brain) during abstinence blocked compulsive-like …
The synthetic and therapeutic expedition of isoxazole and its …
2018年2月27日 · Kalirajan et al. synthesized isoxazole substituted 9-anilinoacridine derivatives and evaluated them for in vitro antioxidant, as well as cytotoxic activity against Hep2 cell line
Differential Effects of Isoxazole-9 on Neural Stem/Progenitor Cells ...
2015年9月25日 · In this study, we tested the effects of Isx-9 on the three major progenitor cell types in brain, and demonstrated that Isx-9 (i) promotes the differentiation from NSPCs into …
A synthetic small-molecule Isoxazole-9 protects against ... - PubMed
Isoxazole-9 modulated neurogenesis, neuronal activation and structural plasticity of GCNs, and expression of synaptic proteins associated with learning and memory in the DG. These …