CXCL1 : Gene, Promoter, Regulation of Expression, mRNA Stability …
Jan 12, 2022 · We also describe the mechanisms regulating CXCL1 activity in the extracellular space, including proteolytic processing, CXCL1 dimerization and the influence of the ACKR1/DARC receptor on CXCL1 localization. Finally, we explain the role of CXCL1 in cancer and possible therapeutic approaches directed against this chemokine.
The role of CXCL family members in different diseases
Jul 1, 2023 · CXCL9 participates in metabolic-associated fatty liver disease via facilitating the imbalance of Treg/Th17 cells with interferon-gamma, providing another new direction to treat this disease .
Blocking the CXCL1-CXCR2 axis enhances the effects of ... - Nature
Apr 10, 2023 · In our study, CXCL1 induced macrophages to differentiate into M2-like macrophages to promote the proliferation, and EMT of HCC cells; otherwise, blocking the CXCL1-CXCR2 axis with anti-CXCR2 ...
Potential roles and targeted therapy of the CXCLs/CXCR2 axis in …
Apr 1, 2019 · Activation of the CXCLs/CXCR2 axis activates multiple signalling pathways, including the PI3K, p38/ERK, and JAK pathways, and regulates cell survival and migration. The CXCLs/CXCR2 axis plays a vital role in the tumour microenvironment and in recruiting neutrophils to inflammatory sites.
The role of CXCL family members in different diseases - PMC
The relationship of CXCL1 and CRC has been studied. Zhuo et al. had explored the mechanism of actions for CXCL1 affecting the development of CRC, and they found that through the stimulation of NF-κB/P300 signaling pathway CXCL1 facilitated tumor cell proliferation and migration as well as promoted angiogenesis . CXCL2 is no exception.
The interferon-stimulated gene RIPK1 regulates cancer cell …
Apr 12, 2022 · We analyzed gene expression in ICB-sensitive versus ICB-resistant tumor cells and identified a strong association between interferon-mediated resistance and expression of Ripk1, a regulator of tumor necrosis factor (TNF) superfamily receptors.
Induction of CXCL1 by Extracellular Matrix and Autocrine …
Nov 1, 2007 · Four cytokines were overexpressed on 804G-ECM compared with poly- l -lysine: C-X-C motif ligand 1 (CXCL1), CXCL2, interferon-inducible protein-10, and IL-1β. A time-course experiment indicated that maximal induction by 804G-ECM of CXCL1/2 and interferon-inducible protein-10 occurred at 4 h.
The Clinical Significance and Role of CXCL1 Chemokine in ...
May 17, 2023 · To address this gap, this review provides a detailed analysis of CXCL1’s role in gastrointestinal cancers, including head and neck cancer, esophageal cancer, gastric cancer, liver cancer (hepatocellular carcinoma (HCC)), cholangiocarcinoma, pancreatic cancer (pancreatic ductal adenocarcinoma), and colorectal cancer (colon cancer and rectal cancer).
The Potential Importance of CXCL1 in the Physiological State and …
Dec 22, 2022 · CXCL1, a cytokine belonging to the CXC sub-family of chemokines with CXC motif chemokine receptor 2 (CXCR2) as its main receptor, causes the migration and infiltration of neutrophils to the sites of high expression. This implicates CXCL1 in many adverse conditions associated with inflammation and the accumulation of neutrophils.
An IFNγ/CXCL2 regulatory pathway determines lesion localization …
Jul 16, 2018 · We provide evidence for an IFNγ-regulated CXCR2/CXCL2 autocrine/paracrine feedback loop in innate immune cells that determines the location of CNS infiltrates during Th1-mediated EAE. When IFNγ signaling is impaired, myeloid cell production of CXCL2 increases, which promotes brainstem inflammation and results in clinical ataxia.