IFNα enhances the production of IL-6 by human neutrophils activated
2016年1月21日 · In this study, we demonstrate that IFNα, a cytokine that modulates the early innate immune responses toward viral and bacterial infections, potently enhances the production of IL-6 in...
Interplay between interleukin-6 signaling and the vascular
2021年7月12日 · Interleukin-6 (IL-6) plays a crucial role in host defense against infection and tissue injuries and is a bioindicator of multiple distinct types of cytokine storms.
IL-6/ERK signaling pathway participates in type I IFN ... - Nature
2023年2月1日 · Similar approaches also validate the involvement of IL-6/ERK signaling in promoting the IFN-dependent, unconventional M2-skewing phenotype in transitional monocytes.
Elucidating the crosstalk mechanism between IFN-gamma and IL-6 …
2013年2月6日 · Interferon-gamma (IFN-gamma) and interleukin-6 (IL-6) are multifunctional cytokines that regulate immune responses, cell proliferation, and tumour development and progression, which frequently have functionally opposing roles.
Interferon-γ induces interleukin-6 production by neutrophils via …
2021年12月11日 · Our data indicate that IFN-γ upregulates IL-6 production via the JAK1/2-STAT1 pathway in human innate immune cells. Furthermore, this IFN-γ-mediated IL-6 induction via JAK/STAT was downregulated by JAKi.
From the Cover: Interplay Between IFN-γ and IL-6 Impacts the ...
2017年4月26日 · None of these genes were essential for induction of inflammation, however IFN-γ and IL-6 were required for exacerbation of other proinflammatory cytokines. Additionally, lack of IFN-γ or IL-6 impacted expression of genes regulated by either IFN-γ or type I IFN.
The cytokines interleukin-6 and interferon-α induce distinct …
2022年4月16日 · Elevated production of the cytokines interleukin (IL)-6 or interferon (IFN)-α in the central nervous system (CNS) is implicated in the pathogenesis of neurological diseases such as neuromyelitis optica spectrum disorders or cerebral interferonopathies, respectively.
An evolutionary recent IFN/IL-6/CEBP axis is linked to monocyte ...
2019年10月22日 · These results suggest Mtb co-opts an evolutionary recent IFN-IL6-CEBP feed-forward loop, increasing myeloid differentiation linked to severe TB in humans.
IL-6/ERK signaling pathway participates in type I IFN-programmed ...
2023年2月1日 · In our initial transitional monocytes system that mimic the responses of tumor-associated monocytes/macrophages under IFN-based therapy (Fig. 1), we have demonstrated the involvement of IL-4 and IL-6 in mediating the IFN-elicited, unconventional M2 program.
Interdependent and independent roles of type I interferons and IL-6 …
Reconstitution of circulating IL-6 revealed that the role of IFNAR in burrowing activity is mediated via IL-6, while IFN-I and IL-6 have additive effects on hypoactivity, but the role of IFN-I in anorexia is independent of IL-6.