Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis …
Upon exposure to ferroptosis-inducing compounds (e.g., erastin, sorafenib, and buthionine sulfoximine), p62 expression prevented NRF2 degradation and enhanced subsequent NRF2 nuclear accumulation through inactivation of Kelch-like ECH-associated protein 1.
Activation of the P62-Keap1-NRF2 Pathway Protects against Ferroptosis …
Jul 5, 2022 · P62-Keap1-NRF2 signaling pathway is involved in the regulation of ferroptosis in RILI. By activating P62, Keap1 expression was blocked, which converted NRF2 into nuclear for expression, and NRF2 antioxidant signaling pathway is activated, which yields an increase in antioxidant protein production and a decrease in ROS level, and finally ...
Activation of the P62-Keap1-NRF2 Pathway Protects against Ferroptosis …
Jul 5, 2022 · The ROS generated by irradiation might be the original trigger of ferroptosis in RILI. In addition, activation of the P62-Kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2 (NRF2) pathway has been shown to blunt ferroptosis and thus acts as a protective factor.
金医科研∣我院乔田奎教授团队揭示了P62-Keap1-NRF2信号通路参 …
2022年7月5日，国际权威生物学杂志Oxidative Medicine and Cellular Longevity (IF=7.31)发表了复旦大学附属金山医院肿瘤科乔田奎教授团队的最新研究成果“Activation of the P62-Keap1-NRF2 Pathway Protects against Ferroptosis in Radiation-induced lung injury”。
The regulation and function of Nrf2 signaling in ferroptosis …
Jul 17, 2024 · c Upon ferroptosis induction, p62 is activated or upregulated to compete with Nrf2 to bind Keap1, forbidding Nrf2 from proteasomal degradation. On the other hand, p62 is also one of the...
Activation of the p62-Keap1-NRF2 Pathway Protects against Ferroptosis …
In this study, we provide novel evidence that the p62-Keap1-NRF2 antioxidative signaling pathway is a key negative regulator of ferroptosis in HCC cells by transcriptional activation of genes involved in ROS and iron metabolism.
Curcumin inhibits PAT-induced renal ferroptosis via the p62…
Aug 1, 2024 · Curcumin induced accumulation of p62 and its interaction with Keap1 via alleviating the autophagy level, which promoted Nrf2 nuclear translocation and enhancing its antioxidant gene transcriptional activity, so as to inhibit ferroptosis.
Activation of p62-Keap1-Nrf2 Pathway Protects 6 ... - Springer
Aug 8, 2020 · In this study, we aim to explore the protective effect of the p62-Keap1-Nrf2 pathway against 6-hydroxydopamine (6-OHDA)-induced ferroptosis in dopaminergic cells. Firstly, our results demonstrated that 6-OHDA-induced ferroptosis could be observed in vivo zebrafish and in vitro human dopaminergic cell line (SH-SY5Y cells) model.
Activation of KEAP1/NRF2/P62 signaling alleviates high ... - Nature
Jul 17, 2019 · The activation of the KEAP1/NRF2/P62 pathway by tBHQ significantly reduced high Pi-induced oxidative stress and vascular calcification, whereas NRF2 or P62 knockdown with siRNA exacerbated ...
Activation of p62-Keap1-Nrf2 Pathway Protects 6 ... - PubMed
In this study, we aim to explore the protective effect of the p62-Keap1-Nrf2 pathway against 6-hydroxydopamine (6-OHDA)-induced ferroptosis in dopaminergic cells. Firstly, our results demonstrated that 6-OHDA-induced ferroptosis could be observed in vivo zebrafish and in vitro human dopaminergic cell line (SH-SY5Y cells) model.