Reprogramming of fatty acid metabolism in cancer
In this review, we will examine the mechanisms through which cancer cells rewire their fatty acid metabolism with a focus on four main areas of research. (1) The role of de novo synthesis and...
The multifaceted roles of fatty acid synthesis in cancer
2016年9月23日 · Cancer cells activate de novo fatty acid synthesis to provide essential structural components and substrates for the generation of signalling molecules.
Fatty acids in cancer: Metabolic functions and potential treatment
Multiple studies have shown that disordered fatty acids can regulate tumor cell proliferation, metastasis, and drug resistance. Therefore, targeting fatty acid metabolism has become a promising treatment strategy. Here, we mainly present metabolic alterations of fatty acids, the basic components of lipids, in cancer.
Targeting fatty acid metabolism for cancer therapy
2024年9月28日 · This article will discuss the impact of abnormal fatty acid metabolism on cancer development and treatment resistance from the perspective of critical enzymes in each process of fatty acid metabolism and summarize the current clinical research status of drugs targeting fatty acid metabolism combined with tumor suppression.
Anticancer activities of fatty acids and their ... - ScienceDirect
2020年3月15日 · In the first part of our review, we discussed the beneficial effects of free fatty acids (saturated and unsaturated) on the progress of carcinogenesis in different tumor cell lines. We presented various mechanisms proposed in the literature, which explain the possible impact on the cells metabolism.
Fatty acid metabolism and cancer development - ScienceDirect
2016年10月1日 · Reprogramming in fatty acid metabolism plays important roles in providing energy, macromolecules for membrane synthesis and lipid signals during cancer development. Understanding the mechanism of deregulated lipid metabolic pathways in cancer cells would reveal novel therapeutic approaches to combat cancer.
Tumour fatty acid metabolism in the context of therapy ... - Nature
2021年8月20日 · This Review discusses mechanistic links between fatty acid metabolism in cancer cells and disease behaviour and therapy resistance, integrating obesity-associated changes that modify cancer...
Fatty Acid Metabolism and Cancer - PubMed
Although normal cells depend on exogenous lipids to function and survive, excessive amount of body fat has been associated with increased risk for certain human cancers. Cancer cells can redirect metabolic pathways to meet energy demands through …
The multifaceted roles of fatty acid synthesis in cancer
This Review explores how different aspects of FA synthesis promote tumorigenesis and tumour progression. FA synthesis has received substantial attention as a potential target for cancer therapy, but strategies to target this process have not yet translated into clinical practice.
Cellular Fatty Acid Metabolism and Cancer - Cell Press
Cellular proliferation, a common feature of all cancers, requires fatty acids for synthesis of membranes and signaling molecules. Here, we provide a view of cancer cell metabolism from a lipid perspective, and we summarize evidence that limiting fatty acid availability can control cancer cell proliferation.