Pathology Outlines - CD71
2021年5月14日 · CD71 is an integral membrane protein that mediates the uptake of transferrin iron complexes In human tissues, CD71 is more highly expressed in placental syncytiotrophoblast, myocytes, hepatocytes, basal keratinocytes, endocrine cells of the pancreas, spermatocytes and erythroid precursors
Pathology Outlines - AML M6
2020年5月11日 · Acute erythroid leukemia (AML-M6) A neoplastic proliferation of immature cells (undifferentiated or proerythroblastic in appearance) committed exclusively to the erythroid lineage (> 80% of the bone marrow cells are erythroid, with ≥ 30% proerythroblasts), with no evidence of a significant myeloblastic component (Swerdlow: WHO Classification of Tumours …
Pathology Outlines - Megaloblastic anemia
2022年7月13日 · Bone marrow aspirate: Adequate for evaluation. Bone marrow aspirate smear is hypercellular with erythroid hyperplasia, reversal of M:E ratio (1:5). Erythroid precursors show megaloblastic changes, nuclear budding and nuclear irregularity. Myeloid lineage cells are reduced in number. Giant metamyelocytes are seen. Neutrophils show hypersegmentation.
Pathology Outlines - Primary myelofibrosis
The marrow aspirate smears are spicular and cellular. Megakaryocytes are increased and show prominent dysmegakaryopoiesis, including hyper and hyposegmented nuclei and increased N:C ratio. The myeloid:erythroid ratio is approximately 4:1. Erythroid maturation is identified. Myeloid maturation is slightly left shifted.
Pathology Outlines - Pure red cell aplasia
2013年9月1日 · Anti-erythroid antibodies may be detected in some patients Also due to allogeneic bone marrow transplant from ABO incompatible donor (treat with aggressive plasmapheresis) May be due to antibodies to recombinant erythropoietin in those with chronic renal failure
Pathology Outlines - AML with maturation (FAB AML M2)
2013年2月1日 · Erythroid and megakaryocyte precursors may have dysplastic changes Often increased eosinophilic precursors without cytological and cytochemical abnormalities of inv(16)(p13.1q22) Basophils may be increased, rarely mast cell hyperplasia ( Indian J Pathol Microbiol 2007;50:655 )
Pathology Outlines - Chronic myelomonocytic leukemia
2024年3月6日 · Hematopoiesis: trilineage maturation with myelomonocytic hyperplasia and relative erythroid hypoplasia. Megakaryocytes are increased (15/high power field on average) and are dysplastic (pleomorphic increased small or hypolobated forms, many with hyperchromatic nuclei, rarely with separation of nuclear lobes.
Aplastic anemia (AA) - Pathology Outlines
2020年3月30日 · Bone marrow aspirate cell count (performed on 150 cells) reveals: 1% blasts, 25% promyelocytes / myelocytes, 11% maturing granulocyte forms, 9% erythroid precursors, 31% lymphocytes, 15% plasma cells, 2% eosinophils, 5% mast cells, 1% monocytes. Prussian blue iron stain shows normal storage iron; no ring sideroblasts are noted.
Pathology Outlines - Systemic mastocytosis
2023年8月7日 · Comment: Microscopic examination of the bone marrow aspirate demonstrates a spicular and cellular specimen which is adequate for evaluation. There is trilineage hematopoiesis. Erythroid precursors demonstrate normoblastic maturation. Myeloid precursors demonstrate the full spectrum of maturation. The myeloid to erythroid (M:E) ratio is normal ...
Pathology Outlines - MDS with mutated SF3B1
2024年9月19日 · Morphology: erythroid lineage dysplasia, ring sideroblasts are present in over 90% cases but not required for diagnosis in the presence of SF3B1 mutation, blasts 5% in the bone marrow and 2% in the peripheral blood Cytogenetics: absence of 5q deletion, monosomy 7/7q deletion or complex karyotype