[(WR)8WKβA]-Doxorubicin Conjugate: A Delivery System to …
Confocal microscopy images confirmed the ability of both Dox conjugate and the physical mixture of the peptide with the drug to deliver Dox through an endocytosis-independent pathway, as the uptake was not inhibited in the presence of endocytosis inhibitors.
New Transferrin Receptor-Targeted Peptide–Doxorubicin Conjugates ...
2024年4月12日 · Poor selectivity to tumor cells is a major drawback in the clinical application of the antitumor drug doxorubicin (DOX). Peptide–drug conjugates (PDCs) constructed by modifying antitumor drugs with peptide ligands that have high affinity to certain overexpressed receptors in tumor cells are increasingly assessed for their possibility of tumor ...
Synthesis of doxorubicin–peptide conjugate with multidrug …
2005年11月15日 · Images (A and B) are from doxorubicin treated cells, and images (C and D) are from doxorubicin–TAT conjugate treated cells. (A and C) Contrast and (B and D) fluorescent images, respectively. Next, we compared tumor killing ability of doxorubicin–TAT conjugate with that of free doxorubicin.
Doxorubicin conjugated with a trastuzumab epitope and an MMP …
Keywords: Doxorubicin-peptide conjugate, trastuzumab epitope, MMP-2 sensitive peptide linker, HER2-positive breast cancer, multiple targets. 1. Introduction ... Images were acquired at room temperature with an inverted fluorescence microscope (Leica, DMI3000B, Wetzlar, Germany). 2.8. Inhibition of HER2 signaling
Design and application of hybrid cyclic-linear peptide-doxorubicin ...
2021年12月15日 · Hybrid cyclic-linear peptide [R 5 K]W 7 A and linear peptide R 5 KW 7 A were conjugated with Dox through a glutarate linker to afford [R 5 K]W 7 A-Dox and R 5 KW 7 A-Dox conjugates to generate Dox derivatives. Alternatively, [R 5 K]W 7 C was conjugated with Dox via a disulfide linker to generate [R 5 K]W 7 C-S-S-Dox
A doxorubicin–peptide–gold nanoparticle conjugate as a …
2022年5月25日 · In this contribution, we apply a combination of atomistic molecular dynamics simulations and density functional theory calculations to characterize a multi-component DDS for the transport of the anthracycline antibiotic doxorubicin (DOX), comprising a gold nanoparticle (NP) and a drug-binding peptide (DBP) grafted on the NP surface.
Morphological transformation enhances Tumor Retention by …
2020年7月9日 · In this work, we reported doxorubicin-peptide conjugates (DPCs) with an extracellular tumor acid-responsive sphere-fiber transformation for enhanced residence in tumors. As illustrated in Scheme Scheme1, 1 , the chemotherapy drug doxorubicin (DOX) was coupled with a peptide (KIGLFRWR) to design a DPC molecule with assembly ability.
Doxorubicin-reinforced supramolecular hydrogels of RGD-derived peptide ...
2019年3月25日 · To address this problem, we report the design and synthesis of a RGD-derived peptide conjugate (1-RGDH) for its co-assembly with a commonly used chemotherapeutic drug, doxorubicin (DOX), that formed electrostatic interactions with the 1-RGDH peptide and reinforced the supramolecular network of nanofibers within the matrix of the hydrogel.
Tumor-specific delivery of doxorubicin through conjugation …
2017年8月7日 · In this study, we prepared a peptide-Dox conjugate aimed at offering Dox molecules a tumor-specific functionality and improving the therapeutic effects of Dox against resistant tumor cells. A slightly acidic pH-sensitive peptide (SAPSP) with high selectivity for cancer cells was attached to Dox to obtain SAPSP-Dox prodrug.
New Transferrin Receptor-Targeted Peptide-Doxorubicin Conjugates ...
2024年4月12日 · Poor selectivity to tumor cells is a major drawback in the clinical application of the antitumor drug doxorubicin (DOX). Peptide-drug conjugates (PDCs) constructed by modifying antitumor drugs with peptide ligands that have high affinity to certain overexpressed receptors in tumor cells are increasi ….