Nucleoside triphosphate - Wikipedia
A nucleoside triphosphate is a nucleoside containing a nitrogenous base bound to a 5-carbon sugar (either ribose or deoxyribose), with three phosphate groups bound to the sugar. [1] They are the molecular precursors of both DNA and RNA, which are chains of nucleotides made through the processes of DNA replication and transcription. [2]
Deoxynucleotide Triphosphates (dNTP): Definition & Overview
2022年5月16日 · Deoxynucleotide triphosphate (dNTP) is a monomeric unit of DNA and formed by reducing ribonucleotides with the enzyme ribonucleotide reductase (RNR). It contains a nitrogen base, bound to deoxyribose sugar, and three phosphate groups attached to its 5’ carbon.
Quantitation of deoxynucleoside triphosphates by click reactions …
2020年1月17日 · The levels of the four deoxynucleoside triphosphates (dNTPs) are under strict control in the cell, as improper or imbalanced dNTP pools may lead to growth defects and oncogenesis.
Deoxynucleoside triphosphate (dNTP) synthesis and destruction …
Deoxynucleoside triphosphates (dNTPs), the substrates for DNA polymerizing enzymes, have long been known to be limited in their concentration in cells because the enzyme that synthesizes deoxynucleotides from ribonucleotides, ribonucleotide reductase (RNR), is synthesized and enzymatically activated as cells enter the S phase (1, 2).
SAMHD1 Functions and Human Diseases - PubMed
2020年3月31日 · Deoxynucleoside triphosphate (dNTP) molecules are essential for the replication and maintenance of genomic information in both cells and a variety of viral pathogens. While the process of dNTP biosynthesis by cellular enzymes, such as ribonucleotide reductase (RNR) and thymidine kinase (TK), has bee ….
Mitochondrial purine and pyrimidine metabolism and beyond
Carefully balanced deoxynucleoside triphosphate (dNTP) pools are essential for both nuclear and mitochondrial genome replication and repair. Two synthetic pathways operate in cells to produce dNTPs, e.g., the de novo and the salvage pathways.
Quantitation of cellular deoxynucleoside triphosphates
2009年12月11日 · Deoxyribonucleoside and ribonucleoside triphosphates in extracts from cycling and confluent human fibroblasts. dNTPs were determined by the original enzymatic method (23), by the enzymatic method described here or by HPLC. rNTPs were measured by HPLC.
Deoxynucleoside triphosphate (dNTP) synthesis and destruction …
2013年8月27日 · Deoxynucleoside triphosphate (dNTP) synthesis and destruction regulate the replication of both cell and virus genomes. Proc Natl Acad Sci U S A. 2013 Aug 27;110 (35):14120-1. doi: 10.1073/pnas.1312901110. Epub 2013 Aug 14.
A Critical Balance: dNTPs and the Maintenance of Genome Stability - MDPI
2016年12月6日 · A crucial factor in maintaining genome stability is establishing deoxynucleoside triphosphate (dNTP) levels within a range that is optimal for chromosomal replication. Since DNA replication is relevant to a wide range of other chromosomal activities, these may all be directly or indirectly affected when dNTP concentrations deviate from a ...
A Critical Balance: dNTPs and the Maintenance of Genome Stability
A crucial factor in maintaining genome stability is establishing deoxynucleoside triphosphate (dNTP) levels within a range that is optimal for chromosomal replication. Since DNA replication is relevant to a wide range of other chromosomal activities, these may all be directly or indirectly affected when dNTP concentrations deviate from a ...