Cynomolgus monkey embryo model captures gastrulation and …
2023年4月6日 · Our results reveal the capacity of in vitro gastrulation and in vivo early pregnancy of cynomolgus monkey blastoids, providing a useful system to dissect primate embryonic development without the same ethical concerns and access challenges in human embryo study.
Cynomolgus monkey embryo model captures gastrulation and …
2023年4月6日 · Stem cell-based embryo models provide a useful system for studying early embryonic development. Li and colleagues reported the generation of cynomolgus monkey blastoids with similar characteristics to natural blastocysts.
A reference single-cell regulomic and transcriptomic map of cynomolgus …
2022年7月13日 · Here we present a compendium of cell types across multiple organs in cynomolgus monkeys (Macaca fascicularis) using both single-cell chromatin accessibility and RNA sequencing data.
TALEN-based generation of a cynomolgus monkey disease model …
2016年8月9日 · This monkey model may help us elucidate the role of MCPH1 in the pathogenesis of human microcephaly and better understand the function of this protein in the evolution of primate brain size.
New monkey embryo models—it’s getting complicated - Cell Press
2023年4月6日 · Li et al. report on the generation of cynomolgus monkey models of blastocyst-stage embryos (called “blastoids”) using naive cynomolgus embryonic stem cells.
An accelerated Parkinson’s disease monkey model using ... - Cell …
2024年10月21日 · We report the development of a cynomolgus monkey model of PD that combines adeno-associated virus (AAV)-mediated overexpression of α-synuclein into the substantia nigra with an injection of poly (ADP-ribose) (PAR) into the striatum.
Construction of cynomolgus monkey type 2 diabetes models by …
3 天之前 · In this study, we identified 80 candidate variants associated T2D by targeted capture sequencing of 61 normal and 81 T2D cynomolgus monkeys. Using these variants and 8 machine learning algorithms, we constructed T2D prediction models, among which the model of SVM with polynomial performed best, and applied the prediction model on another 22 ...
(C) Karyotype analysis of primed and naïve cynomolgus monkey ESCs in each condition. ESCs into trophectoderm and hypoblast lineages at indicated time points. Scale bars, 100. μm. a 1:1 mixture...
In vitro culture of cynomolgus monkey embryos beyond early ... - Science
Histological and immunofluorescent staining, combined with single-cell RNA-sequencing (RNA-seq) analysis, demonstrated that these in vitro–cultured (IVC) monkey embryos developed beyond early gastrulation and recapitulated key events of early primate in …
A cynomolgus monkey model of temporal lobe epilepsy
Non-human primates are attractive models for studying the pathogenic mechanisms of TLE, with the goal of developing new drugs and interventions. In this study, we developed and tested a Cynomolgus monkey (Macaca fascicularis) model of TLE.